Nanoparticle-Mediated Drug Delivery and Gene Therapy

Authors

  • Sha Jin,

    1. DNA Resource Center, College of Engineering, University of Arkansas, Fayetteville, Arkansas 72701
    Search for more papers by this author
  • Kaiming Ye

    Corresponding author
    1. Biomedical Engineering Program, College of Engineering, University of Arkansas, Fayetteville, Arkansas 72701
    • Biomedical Engineering Program, College of Engineering, University of Arkansas, Fayetteville, Arkansas 72701. Ph: 479–575–5315. Fax: 479–575–7318
    Search for more papers by this author

Abstract

Biomedical application of nanotechnology is a rapidly developing area that raises new prospect in the improvement of diagnosis and treatment of human diseases. The ability to incorporate drugs or genes into a functionalized nanoparticle demonstrates a new era in pharmacotherapy for delivering drugs or genes selectively to tissues or cells. It is envisioned that the transfer of nanoengineering capability into disease therapy will provide constant and concentrated drug delivery to targeted tissues, minimizing systemic side effects and toxicity. We have in this article highlighted the recent state of the art in nanomedicine, focusing particularly on the achievement of nanotechnology in nanoscale drug and gene delivery in vitro and in vivo. In addition, a specific emphasis has been placed on the use of nanotechnology to improve controlled drug release and sustainable drug delivery in solid tumors and on new drug therapies for age-related neurodegenerative disorders.

Ancillary