A theoretical model of erosion and macromolecular drug release from biodegrading microspheres
Article first published online: 12 JUN 2000
Copyright © 1997 Wiley-Liss, Inc. and the American Pharmaceutical Association
Journal of Pharmaceutical Sciences
Volume 86, Issue 12, pages 1464–1477, December 1997
How to Cite
Batycky, R. P., Hanes, J., Langer, R. and Edwards, D. A. (1997), A theoretical model of erosion and macromolecular drug release from biodegrading microspheres. J. Pharm. Sci., 86: 1464–1477. doi: 10.1021/js9604117
- Issue published online: 12 JUN 2000
- Article first published online: 12 JUN 2000
- Manuscript Accepted: 24 AUG 1997
- Manuscript Revised: 24 APR 1997
- Manuscript Received: 27 SEP 1996
References and Notes
- 6Controlled release of bioactive agents from lactide/glycolide polymers. In Biodegradable Polymers as Drug Delivery Systems; Chasin, X., Langer, X., Eds.; Marcel Dekker: New York, 1990; pp 1–41.
- 7Biodegradable microspheres as controlled-release tetanus toxoid delivery systems. Vaccine 1993, 11, 1–8.; ; ; ;
- 9Properties of PolymerssCorrelations with Chemical Structure; Elsevier: Amsterdam, 1972.
- 11As pointed out in the discussion section, the general analysis outlined herein applies to far more general circumstances than those of microparticles into which water tunnels via straight, regularly shaped 'free molecular volume' cylindrical pores.
- 14Degradation of long chain molecules. Trans. Faraday Soc. 1940, 35, 611–618.;
- 22Handbook of Mathematical Functions. Dover: New York, 1965.;
- 23In effect, eqs 41-44 are an explicit method for inverting a triangular matrix.
- 24Conduction of Heat in Solids. Oxford, Oxford University 1959.;
- 25This method of measurement is obviously approximate. Distinct mesopores become apparent by visual inspection of electron microscopic photos8 when mesopores reach a radius of approximately RM ≡ 1 µm. Measuring the rate of growth of pores in the domain RM ≥ 1 µm may or may not be equivalent to measuring the rate constant kcoal.
- 31Macrotransport Processes; Butter-worth-Heinemann, Boston 1993.;
- 32Diffusion in Polymers; Neogi, P., Ed.; Marcel Dekker: New York, 1996; pp 143–171.; 1996 Free-volume theory. In