Here we present and analyze the complete Vostok ice cores deuterium excess record which spans the last four climatic cycles, back to ∼420,000 years B.P. To extract paleoclimate information from this record, we use isotopic modeling showing that changes in deuterium excess (d = δD-8δ18O) of Vostok precipitation reflect changes in the average temperature of oceanic moisture sources. Over the last 250,000 years the deuterium excess is strongly anticorrelated with changes in Earth's obliquity. This reflects changes in the relative contribution of low and high latitudes to the Vostok precipitation, resulting from changes in the latitudinal annual mean insolation gradient governed by the obliquity. However, this modulation by obliquity is not observed prior to 250,000 years B.P. We attribute this difference to the ice flow, the deeper ice under Vostok station having accumulated in a location upstream Vostok, receiving precipitation from different oceanic origins. Despite this difference between the earlier and the later portions of the record, the deuterium excess changes during all the glacial inceptions are similar in amplitude and timing relative to the deuterium decrease. The glacial inceptions are characterized by high deuterium excess, indicating the significant role of the tropics in supplying moisture to the already cold poles.