Over the last 50 years, the polar ice sheets covering Antarctica and Greenland have become natural scientific laboratories. Thanks to their unique environments, they yield discoveries that advance different geophysical disciplines and capture the imagination of the general public. The scientific community interested in sampling polar ice sheets and their substrata has been growing recently, and now incorporates biologists, geologists, geophysicists, glaciologists,and paleo-climatologists. This multidisciplinary interest is opening new research frontiers. Significantly advancing our scientific understanding along many of these frontiers will require targeted sampling strategies and the acquisition of data from arrays of deep access holes on spatial scales ranging from local to continent-wide.