High resolution mid-infrared limb emission spectra observed by the spaceborne Michelson Interferometer for Passive Atmospheric Sounding (MIPAS) showing evidence of cloud interference are analyzed. Using the new line-by-line multiple scattering [Approximate] Spherical Atmospheric Radiative Transfer code (SARTre), a sensitivity study with respect to cirrus cloud parameters, e.g., optical thickness and particle size distribution, is performed. Cirrus properties are estimated by fitting spectra in three distinct microwindows between 8 and 12 μm. For a cirrus with extremely low ice water path (IWP = 0.1 g/m2) and small effective particle size (De = 10 μm) simulated spectra are in close agreement with observations in broadband signal and fine structures. We show that a multi-microwindow technique enhances reliability of MIPAS cirrus retrievals compared to single microwindow methods.