The Halogen Occultation Experiment (HALOE) (version 19) ozone vertical profiles are compared with the data obtained by the second generation Solar Backscatter Ultraviolet (SBUV)/2 instruments from the National Oceanic and Atmospheric Administration’s NOAA-11 and NOAA-16 satellites using its version 8 algorithm. We examine the inverse noise-weighted mean percent differences between the HALOE and SBUV/2 ozone profiles at near coincident points and obtain a bias of less than 9% from 40 to 1.5 mb for the NOAA-11 and NOAA-16 satellite data records, with few exceptions. The weighted root mean square (RMS) differences between the HALOE and SBUV/2 observations are generally between 4 and 15% for pressure levels 40–1.5 mb. The RMS differences are larger for the NOAA-16 SBUV/2 data for higher latitudes. We also analyze the time-dependent differences between the two instruments in order to establish whether there is a significant relative drift. The slopes of time series of differences between the HALOE ozone profiles and the NOAA-11 and NOAA-16 SBUV/2 retrievals are, by and large, less than 1% per year and 2% per year, respectively. These results suggest a changing calibration in the NOAA-11 SBUV/2 instrument. Then we investigate the differences between ozone trends determined by the HALOE and SBUV/2 instruments. Trend differences are less than 0.5% per year in almost all latitude bands at pressure levels 10 and 3 mb. There are statistically significant biases of about 0.7% per year at 5 mb from 20°S to 50°N, and the trend differences are less than 1.3% per year at 60°–30°S.