Where are scientists likely to find the clearest signals of climate change so that they can predict future impacts? The question of where we focus our sampling efforts is not a trivial one due to the complex nature of the landscape of the Earth and the wide and varied impacts of both humans and natural processes on the landscape. As the lowest point in the landscape and as hot spots of carbon cycling, lakes and reservoirs may provide an answer. These inland waters play a disproportionate role in informing us about climate change. They also play an important role in regulating climate change by their contributions to the global carbon cycle.