This study explores the upper tropospheric anticyclone above eastern North America and its influence on the summertime buildup and decay of lightning NOx (LNOx) and thunderstorm outflow. LNOx transport is simulated with a particle dispersion model that releases a LNOx tracer from the locations of millions of cloud-to-ground lightning flashes during May–September 2004 and 2006. On average, upper tropospheric zonal flow in May transitions to a closed anticyclone above northern Mexico and the southern United States in July that strengthens in August and rapidly decays in September. Concentrations of the LNOx tracer reach a maximum above the southern United States and Gulf of Mexico in July and August. Fourteen study sites across North America exhibit high day-to-day variability of the LNOx tracer in the upper troposphere during summer, with the sites most heavily influenced by the North American summer monsoon having the greatest background concentrations. During late spring and September the western sites have low concentrations with little variability. In general, the west coast sites plus Barbados have the most aged thunderstorm outflow, while the east coast sites have the least aged outflow. More than 80% of summertime upper tropospheric NOx above the eastern United States is produced by lightning. To produce the best available observation-based view of upper troposphere NOx above North America, measurements from six aircraft campaigns are combined in a single composite plot. The modeled upper tropospheric NOx matches the general continental-scale distribution of NOx in the composite plot, supporting the dominant role of LNOx in the simulations.