A multidisciplinary team of American and Israeli scientists conducted ocean exploration with a “telepresence” component offshore Israel in September 2010 on board the new E/V Nautilus, which is a reincarnation of the former East German R/V Alexander von Humboldt. This was the first comprehensive geological and biological exploration of the Israel continental margin using deep submergence vehicle systems. Diverse seafloor environments in water depths between 500 and 1300 meters were sampled and imaged using two remotely operated vehicle (ROV) systems, Hercules and Argus. The ROV dives within three areas (Figure 1) investigated high-priority acoustic targets representing geological, biological, or archaeological features as identified by the onboard scientific team. During the dives, biological and geological samples and more than 100 kilometers of high-resolution side-scan sonar data were collected.