We study statistical properties of the number of large earthquakes over the past century. We analyze the cumulative distribution of the number of earthquakes with magnitude larger than threshold M in time interval T, and quantify the statistical significance of these results by simulating a large number of synthetic random catalogs. We find that in general, the earthquake record cannot be distinguished from a process that is random in time. This conclusion holds whether aftershocks are removed or not, except at magnitudes below M = 7.3. At long time intervals (T = 2–5 years), we find that statistically significant clustering is present in the catalog for lower magnitude thresholds (M = 7–7.2). However, this clustering is due to a large number of earthquakes on record in the early part of the 20th century, when magnitudes are less certain.