Slow slip events (SSE) in many subduction zones incrementally stress the adjacent locked megathrust, suggesting that they could potentially either trigger or evolve into damaging earthquakes. We explore this with 2D quasi-dynamic simulations with rate-state friction, dilatancy, and coupled 1D pore-fluid and heat transport. Steady-state weakening friction allows transient slip to nucleate, but is inhibited by dilatant strengthening and destabilized by thermal pressurization. SSE spontaneously nucleate in Low Effective-Stress Velocity-Weakening (LESVW) regions. If the dimension of the LESVW is relatively small the SSE are trapped at its updip end, imparting a strong stress concentration in the locked zone. After several centuries SSE penetrate into the region of higher effective stress, where thermal pressurization eventually leads to dynamic rupture. For larger LESVW regions SSE tend to increase in length with time; ultimately higher slip speeds enhance thermal weakening, leading to dynamic instability within the SSE zone. In both cases the onset of the ultimate SSE is essentially indistinguishable from preceding events.
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 In Cascadia SSE are accompanied by tectonic tremor and are referred to as Episodic Tremor and Slip (ETS). Because ETS there, and in other subduction zones, occur down-dip of the locked megathrust, each event incrementally stresses the zone where damaging quakes nucleate. This suggests that the occurrence of ETS may be useful in anticipating damaging earthquakes [Mazzotti and Adams, 2004].
 Earthquake nucleation is, however, time-dependent, which can cause the probability distribution of triggering times to be spread out relative to the inter-ETS period. In the theory ofDieterich , the time for seismicity to decay to background levels following a step change in stress is denoted ta. If ta is relatively long compared to the duration of ETS events, the seismicity rate is not predicted to peak significantly during the transient. Beeler  argues that this is likely to be the case (citing ta of years to decades), such that earthquake probability is not significantly enhanced by periodic slow slip events.
 Nevertheless, triggered seismicity has been associated with SSE in some localities, including the Boso Peninsula of Japan, where slip events every ∼6 years have been accompanied by earthquakes as large as M 5.3 [Ozawa et al., 2007]. SSE beneath Kilauea volcano are accompanied by swarms of small earthquakes [Segall et al., 2006]. The timing of the GPS displacements relative to the swarm onset, as well as their spatial relationship, suggest that the earthquakes were triggered by static stress changes; the swarm events were thus referred to as “co-shocks” of the SSE [Segall et al., 2006]. The temporal evolution of the swarms is consistent with the SSE induced stress changes and ta on the order of 10 days (based on nearby aftershocks).
 Our simulations show that SSE can evolve directly into dynamic events, rather than trigger a remote nucleation site, a possibility that appears not to have received much attention, although see Dragert et al. .
 We present models of dipping faults in an elastic half-space with depth variable friction and effective stress to represent SSE in subduction zones (Figure 1 in Text S1 in the auxiliary material). Deformation is plane-strain, with slip in thex-direction, and the fault centered ony = 0; z measures depth from the free surface. Fault slip δ is the integral of inelastic shear strain across the fault zone − h/2 ≤ y ≤ h/2. Inelastic deformation within the fault zone is approximated by a friction law, with shear resistance the product of friction coefficient f and effective normal stress σ − p(y = 0). We employ the radiation damping approximation of elastodynamics [Rice, 1993] such that the momentum balance on the fault is
Elastic Green's functions Gτδ and Gσδgive the changes in shear and normal stress, respectively, due to slip (slip-to-normal stress coupling arises due to the free surface).τ0, μ, and vsare respectively nominal stress, shear modulus, and shear-wave speed. Slip at a constant ratev∞ is applied below depth zpl ∼ 52 km. The friction coefficient f is a function of slip speed v (integral of shear strain rate across the shear zone) and state variable θ.We employ the regularized form of the rate-state equations [Rice et al., 2001],
and slip-law state evolution. The heat equation, with thermal diffusivitycth, includes shear heating , where c is specific heat capacity and ρdensity. The shear strain-rate is , where g(y) is a (Gaussian) shaping function, and ∫ g(y)dy = h.
 Changes in pore pressure p follow
where chyd is hydraulic diffusivity, β is compressibility of the fluid and pore space, ϕ is the inelastic component of porosity, and Λ is the thermal pressurization parameter [Rice, 2006]. Dilatancy/compaction acts as a fluid pressure sink/source, and thermal pressurization as a source. We employ a constitutive law for inelastic change in porosity δϕ, motivated by experiments [Samuelson et al., 2009], that follows Segall and Rice , but extended to account for a finite thickness shear zone [Segall and Bradley, 2012]. The latter reference also describes the numerical methods employed here.
 The distribution of frictional properties loosely follows Liu and Rice . The parameter a (‘direct effect’) is given by a = α(T + 273.15), where the nominal α = 3 × 10−5, and T is taken from the Peacock  geotherm. Lab experiments on gabbros [He et al., 2007] show large scatter, but can be interpreted to show a transition from velocity weakening to strengthening behavior at T ∼ 510°C. We parameterize a − b, which gives the steady-state frictional response, as piecewise linear (Figure 1), with three sections: the shallow (low T) region is velocity strengthening; at intermediate depth a − b = − 3.5 × 10−3; while at greater depth friction transitions to a − b > 0 at a depth of ∼45 km.
 Based on seismic imaging studies that suggest near lithostatic pore pressures [Audet et al., 2009], and uniform property simulations [Segall and Bradley, 2012], we take in the depth range 25 to 40 km to be of order 1 MPa. At seismogenic depths MPa, while for z > 47 km is ∼110 MPa. The Low Effective-Stress Velocity-Weakening (LESVW) region is where SSE are anticipated to nucleate [Segall et al., 2010; Segall and Bradley, 2012], and indeed this is observed. Within the LESVW we take dc = 100 μm, increasing for numerical expediency to 1 mm updip (the grid in x would need to be very fine at higher ). The transition in dc takes place at least 2 km updip of the transition in to prevent artifacts at the transition.
 We found that thermal pressurization overwhelms velocity strengthening friction at depth, causing dynamic ruptures to propagate well into the strengthening region. We thus suppress thermal pressurization at depth where a > b. An increase in shear zone thickness would reduce frictional heating; however, we simplify this by artificially increasing the heat capacity. For sufficiently high this is effective at stopping dynamic rupture.
 Numerical results fall into two classes, depending on the size of the LESVW (labeled W) relative to the drained critical nucleation dimension Lc = dcμ′/(σ − p∞)(b − a), where μ′ = μ/(1 − ν). Accounting for incomplete drainage does not change this value significantly (see auxiliary material). An example where the LESVW is relatively small (but W/Lc ∼ 30–50) is shown in Figure 1a. For nearly a century following a dynamic event the fault is relatively quiescent, with creep penetrating updip into the locked zone, at which point slow-slip events (SSE) spontaneously nucleate. Note that, as in many geodetic inversions, there is a “transition zone” between creep at the relative plate velocity,v∞, and the essentially locked fault. In the simulations this transition arises naturally, but is not static; the transition propagates updip as a function of time.
 As has been seen in previous simulations of this type [Segall et al., 2010; Liu and Rubin, 2010; Segall and Bradley, 2012], the SSE are stabilized by dilatancy-induced decreases in pore pressure at the leading edge of the SSE (Figure 2b). This is followed by a very modest increase in pore pressure due to shear heating during the SSE. With time the SSE propagate updip until they hit the boundary where the background effective normal stress increases. In this example, the SSE remain trapped at the boundary of the low region for more than 200 years before a dynamic event occurs (Figure 1a).
 The behavior with larger LESVW (W/Lc ∼ 70) is shown in Figure 1b. Again there is a quiescent period following a dynamic event in which the transition between creeping and locked fault extends updip with time, followed by the spontaneous onset of SSE. The SSE generally propagate farther updip with time, but in this case a dynamic event nucleates before the SSE reach the updip limit of the low region.
 Our focus is on how SSE influence the occurrence of dynamic ruptures, which is quite different in the two examples shown in Figure 1. The behavior for the smaller LESVW region is illustrated in more detail in Figure 3. As successive SSE terminate at the updip end of the low region, they generate a stress concentration within the nominally locked zone. Toward the end of the interseismic cycle, SSE propagate slightly into the higher region. While the details depend on the distribution, slow slip in the high region generates significantly more frictional heat. As the ultimate SSE penetrates the higher region, thermal pressurization induces an increasing loss of strength and the rupture becomes unstable. The ensuing strong stress concentration at the rupture tip allows the dynamic event to propagate into the locked zone with only modest (few MPa) stress drop.
 Nucleation of a dynamic event in the larger LESVW case is illustrated in Figure 4. As shown in Figure 1b the SSE generally propagate updip with time. This brings the SSE front into increasingly velocity weakening regions. In addition, the maximum slip speed during SSE is an increasing function of rupture length [Segall et al., 2010], such that the slip speeds increase slightly with time. Although there is no clear increase in maximum slip speed over the last several SSE, increased slip speed enhances thermal pressurization. The onset of the ultimate SSE is unremarkable, and essentially indistinguishable from the preceding events. However, the slip speed eventually reaches a point where thermal pressurization becomes the dominant weakening mechanism [Schmitt et al., 2011]. At this point slip accelerates to inertial speeds within the SSE zone, and then propagates updip.
 We have discussed three ways in which SSE can influence the occurrence of earthquakes: 1) static stress perturbations due to SSE cause nucleation of a dynamic event updip of the SSE zone; 2) SSE extend partially into the locked, higher region where enhanced weakening causes the rupture to accelerate; and 3) SSE extend gradually updip with time, ultimately initiating dynamic rupture within the SSE zone.
 Our numerical simulations do not exhibit mechanism 1, presumably because the model is too smooth (both in terms of fault geometry and/or material properties) to induce sufficient local stress concentrations. In the auxiliary material, we show that the stressing rate, , due to repeated SSE can be approximated by
where lis the half-width of the SSE zone,ξ = x′/l is normalized distance from the SSE zone center (x′ = 0). Equation (4) is in good agreement (Figure 5a) with the average rate of stress accumulation from the time the SSE first reach the updip end of the LESVW region (Figure 1a) to the time just prior to dynamic rupture. Equation (4) can be used to estimate the magnitude of an isolated stress heterogeneity within the locked zone required to trigger a dynamic rupture, assuming that the width of the heterogeneity is sufficiently large to permit unstable slip (that is, the width exceeds some multiple of Lc). Nucleation requires the shear stress to reach the static strength . Thus, for a stress heterogeneity of magnitude Δτ, an estimate of the time to instability is , where τres ∼ 0.5 MPa is the residual stress after dynamic events. Figure 5b shows that stress concentrations Δτ an appreciable distance from the top of the ETS zone would have to be of order 5 MPa (comparable to an earthquake stress drop) in order to nucleate an instability in ≤ 500 years. While stress concentrations of this scale could arise due to previous partial ruptures [Lapusta and Rice, 2003], non-planar fault geometry, or other factors, they do not arise in the simulations here.
 With mechanism 3, dynamic events nucleate within the SSE zone. Dynamic rupture within the SSE zone appears to be contradictory to observations from the Nankai region Japan, where the 1944–1946 Tonankai and Nankaido earthquakes apparently occurred updip of the ETS zone [Dragert et al., 2004]. It is possible that fault properties strictly prohibit fast slip within the ETS zone, although that is not the case for the class of models here, and indeed mechanism 2 dynamic events also rupture into the ETS zone (Figure 1a). Increasing the shear zone thickness hwithin the LESVW region to suppress thermal pressurization does not prevent dynamic events from propagating through the ETS region, at least for the parameter ranges considered. We also examined drained models with a v-cutoff, such that friction becomes velocity strengthening above a critical threshold [Shibazaki and Shimamoto, 2007], and find that this too fails to prevent dynamic events from propagating through the ETS region. This occurs simply because the increase in friction f at very low yields a small increase in strength, one that cannot compensate for the large stress drop updip of the ETS zone. Understanding what limits fast slip from penetrating the ETS zone is an important outstanding mechanical problem.
 Mechanism 2 is likely the most intuitive. If SSE are limited in depth extent by a change in physical properties and/or background effective stress, the repeated SSE produce a stress concentration at the top of the ETS zone. Limited penetration of the SSE into the higher region causes thermal pressurization that is sufficient to allow rupture to accelerate to inertial limits. It is notable that there does not appear to be any obvious change in SSE behavior prior to the onset of a dynamic event, in terms of repeat time, maximum slip speed, or amount of slip in an SSE.
 We can use (4) to make a rough estimate of the recurrence time for dynamic events, assuming that the stress concentration at the top of the SSE region must reach the static strength over a critical nucleation dimension, which we take to be κLc. Thus, where ξ∗ ≡ − 1 − κLc/l. For the simulation in Figure 3 the ultimate SSE penetrates ∼ 700 m into the high region (κ ∼ 7). This corresponds to ξ∗ = − 1.01 and a predicted recurrence time of 290 years. This is of the order of the simulated recurrence interval of 300 years, although the simple estimate does not account for the more than 100 years before the SSE actually reach the updip boundary of the LESVW region.
 The critical dimension W for the transition in behavior between that observed in Figures 1a and 1b is controlled more by thermal pressurization than dilatancy. Properties are nonuniform so the dimensionless parameters are only approximately defined, but a reasonable estimate is Ep = 1.4 × 10−3, a/b = 0.95 (see the auxiliary material for definitions). Segall et al.  presented isothermal simulations that show for Ep = 0.001 and a/b = 0.9, dilatancy stabilizes slip to at least W/Lc > 20, and quite likely much more. Thus, it is not surprising that dilatancy can stabilize slip for W/Lc ∼ 30–50. For the case in Figure 1b the friction becomes more velocity weakening as slip propagates updip. Schmitt et al. compute a critical velocity for which, in the absence of dilatancy, thermal pressurization overwhelms rate-state friction and becomes the dominant weakening mechanism. The behavior is different for aging-law and slip-law friction, but the effect of dilatancy is to make nucleation more like aging law simulations. In this caseSchmitt et al.  find the critical velocity can be approximated by
where q(a, b) is a function of the rate-state parameters. Note thatvcrit is independent of normal stress. For b − a ∼ 2 × 10−3, Schmitt et al. [2011, Figure 13] find vcrit on the order of 10−5 m/s, which is comparable to the slip speed in Figure 4 at the point slip becomes unstable. Thus, the current simulations are consistent with previous experience and suggest that thermal pressurization induces the dynamic event, rather than W/Lc becoming too large for dilatancy to stabilize slip. We have confirmed this with a comparable simulation of the larger W/Lc case without thermal pressurization; as expected, SSE extend to the updip transition, where eventually the dynamic event nucleates.
 Relatively smooth models with depth dependent friction and effective normal stress show that slow-slip events evolve into dynamic ruptures, rather than triggering them by static stress transfer. Two mechanisms are identified, one in which dynamic rupture initiates at the updip margin of the SSE zone, the other in which fast slip initiates within the SSE zone. If either process occurs in nature the probability of a dynamic rupture does increase during ETS events. In neither case, however, is there obvious indication that dynamic instability is imminent prior to the event.
 We thank the two anonymous reviewers for comments, as well as USGS (G11AP20047) and NSF (EAR-0838267) for support.
 The Editor thanks two anonymous reviewers for assisting in the evaluation of this paper.