The fast Radiative Transfer for Television Infrared Observation Satellite (TIROS) Operational Vertical Sounder (RTTOV) (Version 9.3) model was used for simulating the effect of East Asian dust on top of atmosphere radiances. The size distribution of Asian dust was retrieved from nine years of sky radiometer measurements at Dunhunag located in the east of Taklimakan desert of China. The default surface emissivity in RTTOV was replaced by the geographically and monthly varying data from University of Wisconsin (UW)/Cooperative Institute for Meteorological Satellite Studies (CIMSS) infrared surface spectral emissivities. For a given size distribution and surface emissivity, the effects of three refractive indices of Optical Properties of Aerosols and Clouds (OPAC) mineral aerosol, dust-like aerosol by Volz, and High Resolution Transmission (HITRAN) quartz were examined. Results indicate that the specification of surface emissivity using geographically and monthly varying UW/CIMSS data significantly improved the performance of the simulation of AIRS brightness temperature (TB) difference (BTD) between window channels, in comparison to the results from the use of default emissivity value of 0.98 in the RTTOV model, i.e., increase of the correlation coefficient from 0.1 to 0.83 for BTD between 8.9 μm and 11 μm, and from 0.31 to 0.61 for BTD between 3.8 μm and 11 μm. On the other hand, the use of Asian dust size distributions contributed to a general reduction of radiance biases over dust-sensitive window bands. A further improvement of the TB simulations has been made by considering the Volz refractive index, suggesting that hyperspectral infrared remote sensing of Asian dust can be improved using the proper optical properties of the dust and surface emissivity.