Fisheries collapse in the Pacific Northwest. Fisheries resurge in Alaska. Such headlines reflect changes in the Pacific biosphere, occurring at all trophic levels from plankton through seabirds and at all scales from a few kilometers of patchiness to nearly synchronous changes across distances of 10,000 km. Are the large-scale, Pacific-wide changes in the biosphere a response to changes in the physical ocean environment, itself linked to large-scale, ocean-atmosphere changes? Plankton biologists, fisheries researchers, marine mammals and birds specialists, physical oceanographers, statisticians, and climate dynamicists tackled this question at the 10th [Aha Huliko]a Hawaiian Winter Workshop.