Very long base line interferometry (VLBI) observations of lunar radio transmitters have been combined with data from laser ranging to lunar retroreflectors to estimate simultaneously (1 ) parameters in models of the lunar orbit and libration and (2) the selenodetic coordinates of the radio transmitters and retroreflectors. For the ratio of the mass of the sun to that of the earth plus moon we obtain 328,900.50 ±0.03. For the lunar moment-of-inertia ratios we find β[≡ (C - A )/B] = (631.27 ± 0.03)× 10−6and γ [ ≡(B - A)/C] = (227.7 ± 0.7) × 10−6. The value implied for C/MR2 is 0.392 ± 0.003, the uncertainty being dominated by that of the coefficient J2 of the second zonal gravity harmonic, obtained by Gapcynski et al. from analysis of Explorer spacecraft orbital data. The values and most of the uncertainties that we obtain for the third-degree harmonics of the moon's gravity field are comparable to those which have been obtained by others from observations of lunar orbiting spacecraft. However, our determination of β appears to be the best available, and our results for the two third-degree gravity coefficients C31= (26 ± 4) × 10−6 and C33 = (2 ± 2) × 10−6 have much less uncertainty than determinations based on laser data alone. For the relative position vectors of the lunar radio transmitters and the retroreflectors our estimates have uncertainties of about 30 m along the earth-moon direction and about 10 m in each of the two transverse coordinates.