Sensitivity to fungal allergens is a risk factor for life-threatening asthma
Article first published online: 9 OCT 2008
Volume 55, Issue 5, pages 501–504, May 2000
How to Cite
Black, P. N., Udy, A. A. and Brodie, S. M. (2000), Sensitivity to fungal allergens is a risk factor for life-threatening asthma. Allergy, 55: 501–504. doi: 10.1034/j.1398-9995.2000.00293.x
- Issue published online: 9 OCT 2008
- Article first published online: 9 OCT 2008
- Accepted for publication 20 December 1999
- fungal allergens
Background: Previous studies have suggested that sensitivity to Alternaria and Cladosporium may be risk factors for life-threatening asthma. We have investigated this by studying the relationship between skin tests for fungal spores and admission to an intensive care unit (ICU) for asthma.
Methods: Skin prick tests for fungal spores (Alternaria tenuis, Cladosporium cladosporoides, Helminthosporium maydis, and Epicoccum nigrum), cat dander, house-dust mite (Dermatophagoides pteronyssinus), and a seven-grass mix were performed in three groups of patients: patients admitted to an ICU with an attack of asthma; those who had received emergency treatment for asthma but had not been admitted to an ICU, and those who had never required emergency treatment for their asthma.
Results: Twenty of 37 patients (54%) admitted to the ICU had a positive skin test for one or more fungal allergens compared with 15/50 patients (30%) in each of the other groups (P=0.005). The ICU patients were no more likely to have positive skin tests for the grass mix, cat dander, or house-dust mite than the other patients.
Conclusions: A positive skin test for fungal allergens is a risk factor for admission to an ICU with an acute attack of asthma.