• 1
    Woolcock AJ, Peat JK. Evidence for the increase in asthma worldwide. Ciba Foundation Symp 1997;206:122134.
  • 2
    Bjorksten B, Dumitrascu D, Foucard T et al. Prevalence of childhood asthma, rhinitis and eczema in Scandinavia and Eastern Europe. European Respiratory J 1998;12:432437.
  • 3
    Holberg CJ, Elston RC, Halonen M et al. Segregation analysis of physician-diagnosed asthma in Hispanic and non-Hispanic white families. A recessive component? Am J Respiratory Crit Care Med 1996;154:144150.
  • 4
    Marsh DG, Neely JD, Breazeale DR et al. Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations. Science 1994;264:11521156.
  • 5
    Johansson SGO, O'bhourihane J, Bousquet J et al. A revised nomenclature for allergy. An EAACI position statement from the EAACI nomenclature task force. Allergy 2001;56:813824.
  • 6
    Von Mutius E, Martinez FD, Fritzsch C, Nicolai T, Roell G, Thiemann HH. Prevalence of asthma and atopy in two areas of West and East Germany. Am J Respiratory Crit Care Med 1994;149:358364.
  • 7
    Strachan DP. Hay Fever, hygiene, and household size. BMJ 1989;299:12591260.
  • 8
    Martinez FD. Role of viral infections in the inception of asthma and allergies during childhood: could they be protective? Thorax 1994;49:11891191.
  • 9
    Holt PG. Environmental factors and primary T-cell sensitisation to inhalant allergens in infancy: reappraisal of the role of infections and air pollution. Pediatric Allergy Immunol 1995;6:110.
  • 10
    Holt PG, Macaubas C. Development of long-term tolerance versus sensitisation to environmental allergens during the perinatal period. Current Opinion Immunol 1997;9:782787.
  • 11
    Sudo N, Sawamura S, Tanaka K, Aiba Y, Kubo C, Koga Y. The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction. J Immunol 1997;159:17391745.
  • 12
    Yoshimoto T, Nagai N, Ohkusu K, Ueda H, Okamura H, Nakanishi K. LPS-stimulated SJL macrophages produce IL-12 and IL-18 that inhibit IgE production in vitro by induction of IFN-gamma production from CD3intIL-2R beta+ T cells. J Immunol 1998;161:14831492.
  • 13
    Romagnani S. Induction of TH1 and TH2 responses: a key role for the ‘natural’ immune response? [see comments]. Immunol Today 1992;13:379381.
  • 14
    Holt PG, Sly PD, Bjorksten B. Atopic versus infectious diseases in childhood. a question of balance? Pediatric Allergy Immunol 1997;8:5358.
  • 15
    Hilkens CM, Kalinski P, De Boer M, Kapsenberg ML. Human dendritic cells require exogenous interleukin-12-inducing factors to direct the development of naive T-helper cells toward the Th1 phenotype. Blood 1997;90:19201926.
  • 16
    Macatonia SE, Hosken NA, Litton M et al. Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells. J Immunol 1995;154:50715079.
  • 17
    Shanks N, Windle RJ, Perks PA et al. Early-life exposure to endotoxin alters hypothalamic-pituotary-adrenal function and predisposition to inflammation. Proc Natl Acad Sci USA 2000;97:56455650.
  • 18
    Prescott SL, Macaubas C, Smallacombe T, Holt BJ, Sly PD, Holt PG. Development of allergen-specific T-cell memory in atopic and normal children [see comments]. Lancet 1999;353:196200.
  • 19
    . The Collaborative Study on the Genetics of Asthma. A genome-wide search for asthma susceptibility loci in ethnically diverse populations. Nature Genet 1997;15:389392.
  • 20
    Martinez FD, Solomon S, Holberg CJ, Graves PE, Baldini M, Erickson RP. Linkage of circulating eosinophils to markers on chromosome 5q. Am J Respiratory Crit Care Med 1998;158:17391744.
  • 21
    Walley AJ, Wiltshire S, Ellis CM, Cookson WOCM. Linkage and Allelic Association of Chromosome 5 Cytokine Cluster Genetic Markers with Atopy and Asthma Associated Traits. Genomics 2001;72:1520.
  • 22
    Ulevitch RJ, Tobias PS. Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin. Annu Rev Immunol 1995;13:437457.
  • 23
    Yoshida A, Koide Y. Arabinofuranosyl-terminated and mannosylated lipoarabinomannans from Mycobacterium tuberculosis induce different levels of interleukin-12 expression in murine macrophages. Infection Immunity 1997;65:19531955.
  • 24
    Gupta D, Kirkland TN, Viriyakosol S, Dziarski R. CD14 is a cell-activating receptor for bacterial peptidoglycan. J Biol Chem 1996;271:2331023316.
  • 25
    Verhasselt V, Buelens C, Willems F, De Groote D, Haeffner-Cavaillon N, Goldman M. Bacterial lipopolysaccharide stimulates the production of cytokines and the expression of costimulatory molecules by human peripheral blood dendritic cells: evidence for a soluble CD14-dependent pathway. J Immunol 1997;158:29192925.
  • 26
    Pugin J, Heumann ID, Tomasz A et al. CD14 is a pattern recognition receptor. Immunity 1994;1:509516.
  • 27
    Steinman RM. The dendritic cell system and its role in immunogenicity. Annu Rev Immunol 1991;9:271296.
  • 28
    Freudenthal PS, Steinman RM. The distinct surface of human blood dendritic cells, as observed after an improved isolation method. Proc Natl Acad Sci United States America 1990;87:76987702.
  • 29
    Cohen L, Haziot A, Shen DR et al. CD14-independent responses to LPS require a serum factor that is absent from neonates. J Immunol 1995;155:53375342.
  • 30
    Landmann R, Knopf HP, Link S, Sansano S, Schumann R, Zimmerli W. Human monocyte CD14 is upregulated by lipopolysaccharide. Infection Immunity 1996;64:17621769.
  • 31
    Baldini M, Lohman IC, Halonen M, Erickson RP, Holt P, Martinez FD. A polymorphism in the 5′-flanking region of the CD 14 gene is associated with circulating soluble CD14 levels and with total serum IgE. Am J Respiratory Cell Mol Biol 1999;20:976983.
  • 32
    Gao P, Mao X, Baldini M et al. Serum total IgE levels and CD14 on chromosome 5q31. Clinical Genetics 1999;56:164165.
  • 33
    Koppelman GH, Reijmerink NE, Colin Stine O et al. Association of a promoter polymorphism of the CD14 gene and atopy. Am J Respiratory Crit Care Med 2001;163:965969.
  • 34
    Levan TD, Bloom J, Bailey T et al. A common single nucleotide polymorphism in the CD14 promoter decreases the affinity of Sp protein binding and enhances trascriptional activity. J Immunol 2001;167:58385844.
  • 35
    Von Ehrenstein OS, Von Mutius E, Illi S, Baumann L, Bohm O, Von Kries R. Reduced risk of hay fever and asthma among children of farmers. Clin Exp Allergy 2000;30:187193.
  • 36
    Von Mutius E, Braun-Fahrlander C, Schierl R et al. Exposure to endotoxin or other bacterial components might protect against the development of atopy. Clin Exp Allergy 2000;30:12301234.
  • 37
    Hesselmar B, Aberg N, Aberg B, Eriksson B, Bjorksten B. Does early exposure to cat or dog protect against later allergy development? Clin Exp Allergy 1999;29:611617.DOI: 10.1046/j.1365-2222.1999.00534.x
  • 38
    Svanes C, Jarvis D, Chinn S, Burney P. Childhood environment and adult atopy: results from the European Community Respiratory Health Survey. J Allergy Clin Immunol 1999;103:415420.
  • 39
    Moffatt MF, Cookson WO. Genetics of asthma and inflammation: the status. Current Opinion Immunol 1999;11:606609.
  • 40
    Kline JN, Cowden JD, Hunninghake GW et al. Variable airway responsiveness to inhaled lipopolysaccharide. Am J Respiratory Crit Care Med 1999;160:297303.
  • 41
    Tulic MK, Wale JL, Holt PG, Sly PD. Modification of the inflammatory response to allergen challenge after exposure to bacterial lypopolisaccharide. Am J Respiratory Cell Mol Biol 2000;22:604612.
  • 42
    Amelung PJ, Weisch DG, Xu J, Paigen B, Meyers DA, Bleecker ER. A polymorphism in CD14 is associated with high IgE levels in a population with laboratory animal allergy. Am J Respiratory Crit Care Med 2000;161:A927.
  • 43
    Ober C, Tsalenko A, Parry R, Cox NJ. A Second-Generation Genomwide Screen for Asthma-Susceptibility Alleles in a Founder Population. Am J Human Genet 2000;67:11541162.
  • 44
    Baldini M, Kabesch M, Graves PE, Erickson RP, Vercelli D, Martinez FD. Detection of four novel polymorphisms in the CD14 promoter and association of their haplotypes with total serum IgE levels. Am J Respiratory Crit Care Med 2000;161:A928.
  • 45
    Vercelli D, Baldini M, Martinez FD. The Monocyte/IgE Connection: May Polymorphisms in tha CD14 Gene Teach Us about IgE Regulation? Int Arch Allergy Immunol 2001;124:2024.