• 1
    Strachan DP. Family size, infection and atopy: the first decade of the “hygiene hypothesis“. Thorax 2000;55(suppl.):S210.
  • 2
    Matricardi PM. Infections preventing atopy: facts and new questions. Allergy 1997;52: 879882.
  • 3
    Shaheen SO, Aaby P, Hall AJ, Barker DJ, Heyes CB, Shiell AW et al. Measles and atopy in Guinea-Bissau. Lancet 1996;347: 17921796.
  • 4
    Shirakawa T, Enomoto T, Shimazu S, Hopkin JM. The inverse association between tuberculin responses and atopic disorder. Science 1997;275: 7779.
  • 5
    Matricardi PM, Rosmini F, Ferrigno L, Nisini R, Rapicetta M, Chionne P et al. Cross sectional retrospective study of prevalence of atopy among Italian military students with antibodies against hepatitis A virus. Br Med J 1997;314: 9991003.
  • 6
    Ruuskanen O, Ogra PL. Respiratory syncytial virus. Curr Probl Pediatr 1993;23: 5079.
  • 7
    Waris M. Pattern of respiratory syncytial virus epidemics in Finland: two-year cycles with alternating prevalence of groups A and B. J Infect Dis 1991;163: 464469.
  • 8
    Hietala J, Uhari M, Tuokko H. Antigen detection in the diagnosis of viral infections. Scand J Infect Dis 1988;20: 595599.
  • 9
    Asher MI, Keil U, Anderson HR, Beasley R, Crane J, Martinez F et al. International Study of Asthma and Allergies in Childhood (ISAAC): rationale and methods. Eur Respir J 1995;8: 483491.
  • 10
    Koillinen H, Wanne O, Niemi V, Laakkonen E. Reference values for spirometry and peak expiratory flow in healthy Finnish children(in Finnish). Suomen Lääkärilehti 1998;53: 395402.
  • 11
    Malmberg P, Pelkonen A, Poussa T, Pohjanpalo A, Haahtela T, Turpeinen M. Reference values of oscillometry as support in diagnostics of asthma(in Finnish). Duodecim 2001;117: 15411544.
  • 12
    Sigurs N, Bjarnason R, Sigurbergsson F, Kjellman B, Bjorksten B. Asthma and immunoglobulin E antibodies after respiratory syncytial virus bronchiolitis: a prospective cohort study with matched controls. Pediatrics 1995;95: 500505.
  • 13
    von Mutius E, Martinez FD, Fritzsch C, Nicolai T, Roell G, Thiemann HH. Prevalence of asthma and atopy in two areas of West and East Germany. Am J Respir Crit Care Med 1994;149: 358364.
  • 14
    Annus T, Bjorksten B, Mai XM, Nilsson L, Riikjarv MA, Sandin A et al. Wheezing in relation to atopy and environmental factors in Estonian and Swedish schoolchildren. Clin Exp Allergy 2001;31: 18461853.
  • 15
    Welliver RC, Wong DT, Sun M, Middleton E Jr, Vaughan RS, Ogra PL. The development of respiratory syncytial virus-specific IgE and the release of histamine in nasopharyngeal secretions after infection. N Engl J Med 1981;305: 841846.
  • 16
    van Schaik SM, Tristram DA, Nagpal IS, Hintz KM, Welliver RC, Welliver RC. Increased production of IFN-gamma and cysteinyl leukotrienes in virus-induced wheezing. J Allergy Clin Immunol 1999;103: 630636.
  • 17
    van Schaik SM, Obot N, Enhorning G, Hintz K, Gross K, Hancock GE et al. Role of interferon gamma in the pathogenesis of primary respiratory syncytial virus infection in BALB/c mice. J Med Virol 2000;62: 257266.
  • 18
    Maggi E, Parronchi P, Manetti R, Simonelli C, Piccinni MP, Rugiu FS et al. Reciprocal regulatory effects of IFN-gamma and IL-4 on the in vitro development of human Th1 and Th2 clones. J Immunol 1992;148: 21422147.
  • 19
    Peebles RS Jr, Hashimoto K, Collins RD, Jarzecka K, Furlong J, Mitchell DB et al., Immune interaction between respiratory syncytial virus infection and allergen sensitization critically depends on timing of challenges. J Infect Dis 2001;184: 13741379.
  • 20
    Bjorksten F, Suoniemi I. Time and intensity of first pollen contacts and risk of subsequent pollen allergies. Acta Med Scand 1981;209: 299303.
  • 21
    Pullan CR, Hey EN. Wheezing, asthma, and pulmonary dysfunction 10 years after infection with respiratory syncytial virus in infancy. Br Med J (Clin Res Edn) 1982;284: 16651669.
  • 22
    Sims DG, Gardner PS, Weightman D, Turner MW, Soothill JF. Atopy does not predispose to RSV bronchiolitis or postbronchiolitic wheezing. Br Med J (Clin Res Edn) 1981;282: 20862088.
  • 23
    Carlsen KH, Larsen S, Bjerve O, Leegaard J. Acute bronchiolitis: predisposing factors and characterization of infants at risk. Pediatr Pulmonol 1987;3: 153160.
  • 24
    Murray M, Webb MS, O'Callaghan C, Swarbrick AS, Milner AD. Respiratory status and allergy after bronchiolitis. Arch Dis Child 1992;67: 482487.
  • 25
    Sigurs N, Bjarnason R, Sigurbergsson F, Kjellman B. Respiratory syncytial virus bronchiolitis in infancy is an important risk factor for asthma and allergy at age 7. Am J Respir Crit Care Med 2000;161: 15011507.
  • 26
    Mok JY, Simpson H. Outcome of acute lower respiratory tract infection in infants: preliminary report of seven-year follow-up study. Br Med J (Clin Res Edn) 1982;285: 333337.
  • 27
    Noble V, Murray M, Webb MS, Alexander J, Swarbrick AS, Milner AD. Respiratory status and allergy nine to 10 years after acute bronchiolitis. Arch Dis Child 1997;76: 315319.
  • 28
    Remes ST, Korppi M. Asthma and atopy in schoolchildren in a defined population. Acta Paediatr 1996;85: 965970.