• 1
    Holgate ST. Asthma and allergy disorders of civilisation? QJM 1998;57:171184.
  • 2
    Hanson B, McGue M, Roitman-Hohnson B, et al. Atopic disease and immunoglobulin E in twins reared apart and together. Am J Hum Genet 1991;48:873879.
  • 3
    Von Mutius E, Fritsch C, Welland SK, Roll G, Magnussen H. Prevalence of asthma and allergic disorders among children in united Germany: a descriptive comparison. BMJ 1992;305:13951399.
  • 4
    Braback L, Breborowicz , Dreborg S, et al. Atopic sensitisation and respiratory symptoms among Polish and Swedish school children. Clin Exp Allergy 1994;24:826835.
  • 5
    Woolcock AJ, Peat JK. Evidence for the increase in asthma world-wide. In: The Rising Trends in AsthmaVol 206. Ciba Foundation. Wiley, 1997, 122124.
  • 6
    Kaur B, Anderson HR, Austin J, et al. Prevalence of asthma symptoms, diagnosis, and treatment in 12–14 year old children across Britain. BMJ 1998;316:118124.
  • 7
    Ball TM, Castro-Rodriguez JA, Griffith KA, et al. Siblings, day-care attendance, and the rise of asthma and wheezing during childhood. N Engl J Med 2000;343:538543.
  • 8
    Shaheen SO, Aaby P, Hall AJ, et al. Measles and atopy in Guinea-Bissau. Lancet 1996;347:17921817.
  • 9
    Matricardi PM, Rosmini F, Ferigno L, et al. Exposure to foodborne and orofecal microbes versus airborne viruses in relation to atopy and allergic asthma: epidemiological study. BMJ 2000;320:412416.
  • 10
    Strachan DP. Allergy and family size: a riddle worth solving. Clin Exp Allergy 1997;27:235236.
  • 11
    Bjorksten TM, Sepp E, Julge K, et al. Allergy development and intestinal microflora during he first year of life. J Allergy Clin Immunol 2001;108:516520.
  • 12
    Shirakawa T, Enomoto T, Shimazu S, Hopkin JM. The inverse association between tuberculin responses and atopic disorder. Science 1997;275:7779.
  • 13
    Von Mutius, Pearce N, Beasley R, et al. International patterns of tuberculosis and the prevalence of symptoms of asthma, rhinitis, and eczema. Thorax 2000;55:440453.
  • 14
    Erb JK, Holloway JW, Sobeck A, Heidrun M, Le Gros G. Infections of mice with BCG suppresses antigen-induced airway eosinophilia. J Exp Med 1998;187:561569.
  • 15
    Herz U, Gerhold K, Grüber C, et al. BCG infection suppresses allergic sensitization and development of increased airway reactivity in an animal model. J Allergy Clin Immunol 1998;102:867874.
  • 16
    Nahom M-A, Lagranderie M, Lefort J, et al. Effects of Myocobacterium bovis BCG on the development of allergic inflammation and bronchial responsiveness in hyper-IgE BP 2 Mice vaccinated at newborn. Vaccine, in press.
  • 17
    Wang CC, Rook GAW. Inhibition of an established allergic response to ovalbumin in Balb/c mice by killed Mycobacterium vaccae. Immunol 1998;93:307313.
  • 18
    Aaby P, Shaheen SO, Heyes CB, et al. Early BCG vaccination and reduction in atopy in Guinea-Bissau. Clin Exp Allergy 2000;30:644650.
  • 19
    Strannegard IL, Larsson LO, Wennergren G, et al. Prevalence of allergy in children in relation to prior BCG vaccination and infection with atypical mycobacteria. Allergy 1998;3:240254.
  • 20
    Alm JS, Lilja G, Pershagen G, Scheynius A. Early BCG vaccination and development. Lancet 1997;350:400403.
  • 21
    Farooqi IS, Hopkin JM. Early childhood and atopy infection disorder. Thorax 1998;53:927932.
  • 22
    Wickens K, Kemp T, Pearce N, Crane J, Beasley P. Antibiotic use in early childhood and the development of asthma. Clin Exp Allergy; in press.
  • 23
    Alm JS, Swartz J, Lilja G, Scheynius A, Pershangen G. Atopy in children of families with an antroposophic lifestyle. Lancet 1999;353:14851488.
  • 24
    Drostre JHJ, Wieringa MH, Weyler JJ, et al. Does the use of antibiotics in early childhood increase the risk of asthma and allergic disease? Clin Exp Allergy 2000;30:15471553.
  • 25
    Oyama N, et al. Antibiotics during infancy promotes a shift toward Th-2 dominant immunity in mice. J Allergy Clin Immunol 2000;107:153159.
  • 26
    Berg RD. The indigenous gastrointestinal microflora. Trends Microbiol 1996;4:430435.
  • 27
    Kemp T, Pearce N, Fitzharris P, et al. Is infant immunisation a risk factor for childhood asthma or allergy? Epidemiology 1997;678680.
  • 28
    Kristensen I, Aaby P, Jensen H. Routine vaccinations and child survival, follow up study in Guinea-Bissau, West Africa. BMJ 2000;321:14351439.
  • 29
    Gardner SG, Bingley PJ, Sawtell PA, Weeks S, Gale EA. Rising incidence of insulin dependent diabetes in children aged under 5 years in the Oxford region: time trend analysis. The Bart's-Oxford Study Group, BMJ 1997;315:713717.
  • 30
    Parent ME, Siemiatychi J, Menzies R, Fritschi L, Colle E. Vacille Calmette-Geurin vaccination and incidence of IDDM in Montreal. Can Diabetes Care 1997;20:767772.
  • 31
    Martins TC, Aguas AP. Mechanisms of Mycobacterium avium-induced resistance against insulin-dependent diabetes mellitus (IDDM) in non-obese diabetic (NOD) mice: role of Fas and Th-1 cells. Clin Exp Immunol 1999;115:248254.
  • 32
    Van Den Bisselaar AH, Van Ree R, Rodrigues LC, et al. Decreased atopy in children with Schistosoma halmatobium: a role for parasite induced IL-10 .
  • 33
    Moret Y, Schmid-Hempel P. Survival for immunity. Science 2000;290:11661168.DOI: 10.1126/science.290.5494.1166