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Keywords:

  • basement membranes;
  • bone;
  • cartilage;
  • collagen;
  • development;
  • genes;
  • mutations;
  • procollagen

Collagens are some of the majr building blocks of the vertebrate body. In addition to their structural role,they are important for cell guidance during development and for maintaining tissue integrity. In their absence, phenotypes range from lethal to mild. These studies demonstrated that collaens,in their rich array, play important roles in development and are significant elements in reading the developmental code.