Factors influencing sib risks for Multiple Sclerosis


Corresponding author: Dr A Dessa Sadovnick, G920 Detwilller Pavilion, Vancouver Hospital and Health Sciences Centre, UBC Site, 2211 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 2B5. Tel: +604 822 5670; fax: +604 822 7362


Multiple sclerosis (MS) is now thought to be a complex trait determined by genetic and non-genetic (environmental) factors.
The study group, identified from the Canadian Collaborative Project on Genetic Susceptibility to MS, consisted of 1 083 MS index cases, 2 166 of their parents and 3 112 of their sibs. The results, together with those of a previous study on an independent data set, suggest that gender, age of MS onset and having one parent with MS may individually and interactively alter sib risks for MS.
These data are important for genetic counselling and for molecular genetic (genome screens, candidate gene analyses) studies.