Hester van Cruijsen was a visiting medical student from the University of Groningen, the Netherlands, and was supported by the Foundation of Jan Kornelis de Cock Stichling during the conduct of this study.
Detection of simultaneous β-herpesvirus infections in clinical syndromes due to defined cytomegalovirus infection
Article first published online: 28 APR 2003
Volume 17, Issue 2, pages 114–120, April 2003
How to Cite
Razonable, R. R., Rivero, A., Brown, R. A., Hart, G. D., Espy, M. J., Van Cruijsen, H., Wilson, J., Groettum, C., Kremers, W., Smith, T. F. and Paya, C. V. (2003), Detection of simultaneous β-herpesvirus infections in clinical syndromes due to defined cytomegalovirus infection. Clinical Transplantation, 17: 114–120. doi: 10.1034/j.1399-0012.2003.02104.x
Presented in part at the 39th annual meeting of the Infectious Diseases Society of America (2001), San Francisco, CA (abstract 444).
- Issue published online: 28 APR 2003
- Article first published online: 28 APR 2003
- Accepted for publication 18 September 2002
- human herpesvirus-6;
- human herpesvirus-7;
Abstract: Human herpesvirus (HHV)-6 and HHV-7 are increasingly being recognized as emerging pathogens among transplant recipients. Using quantitative polymerase chain reaction assays, we demonstrate the presence of HHV-6 and/or HHV-7 in 18 of 20 episodes of clinically presumed or microbiologically confirmed cytomegalovirus (CMV) infection. Seventeen (89%) of 19 microbiologically confirmed cytomegalovirus (CMV)-infected patients had concomitant HHV-6 variant B (47%) and/or HHV-7 (63%) infection. The degree of HHV-6 coinfection was significantly correlated with hyperbilirubinemia while HHV-7 coinfection demonstrated a non-significant trend toward cytopenias. In one of the 20 episodes described herein, the ‘viral syndrome’ was due solely to HHV-7 infection; clinical and virological response was observed during intravenous ganciclovir therapy in this patient. While this study emphasizes the significance of HHV-6 and/or HHV-7 coinfection during episodes of CMV infection, it significantly highlights the novel observation of the causal role of HHV-7 (in the absence of HHV-6 and CMV) in a clinical illness presumed to be caused CMV. Thus, HHV-7 (and HHV-6) should be considered as a pathogen (or copathogen) in the viral syndromes following organ transplantation.