Susceptible locus for obese type 2 diabetes mellitus in the 5′-flanking region of the tumor necrosis factor-α gene

  1. S. Kamizono1,2,
  2. K. Yamada3,
  3. N. Seki1,
  4. T. Higuchi1,2,
  5. A. Kimura4,
  6. K. Nonaka3,
  7. K. Itoh1

Article first published online: 25 DEC 2001

DOI: 10.1034/j.1399-0039.2000.550508.x

Issue

Tissue Antigens

Tissue Antigens

Volume 55, Issue 5, pages 449–452, May 2000

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How to Cite

Kamizono, S., Yamada, K., Seki, N., Higuchi, T., Kimura, A., Nonaka, K. and Itoh, K. (2000), Susceptible locus for obese type 2 diabetes mellitus in the 5′-flanking region of the tumor necrosis factor-α gene. Tissue Antigens, 55: 449–452. doi: 10.1034/j.1399-0039.2000.550508.x

Author Information

  1. 1

    Department of Immunology, Kurume University School of Medicine, Kurume, Japan

  2. 2

    Department of Pediatrics, Kurume University School of Medicine, Kurume, Japan

  3. 3

    Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine, Kurume, Japan

  4. 4

    Department of Tissue Physiology, Division of Adult Diseases, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan

Publication History

  1. Issue published online: 25 DEC 2001
  2. Article first published online: 25 DEC 2001

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Keywords:

  • diabetes mellitus;
  • obesity;
  • polymorphism;
  • promoter region;
  • TNF-α gene

Abstract:

We have identified three novel polymorphisms in the promoter/enhancer region of the tumor necrosis factor (TNF)-α gene. In this study we investigated the role of the polymorphisms in predisposition to Type 2 diabetes. The allele frequency of C→T substitution at −857 tended to be higher in obese patients with diabetes than in lean subjects with normal glucose tolerance (0.280 vs. 0.190). This tendency was due to a significantly higher ratio of −857T homozygotes in the obese patients with diabetes (15%) than in lean subjects with normal glucose tolerance (4%). There was no significant association between polymorphisms at positions −863 or −1,013, and diabetes. The homozygous −857T allele may be associated with genetic susceptibility to type 2 diabetes in obese subjects.

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