1The names DRB1*0107, *0425, *13012 and DRB4*01033 have been officially assigned by the WHO Nomenclature Committee. This follows the agreed policy that, subject to the conditions stated in the most recent Nomenclature Report (†), names will be assigned to new sequences as they are identified. Lists of such new names will be published in the following WHO Nomenclature Report.
Identification of three new DRB1 alleles, DRB1*0107, *0425 and *13012 and confirmation of DRB4*01033
Article first published online: 12 MAY 2003
Volume 61, Issue 5, pages 398–402, May 2003
How to Cite
Voorter, C.E.M., Hepkema, B.G., Lems, S.P.M. and Van Den Berg-Loonen, E.M. (2003), Identification of three new DRB1 alleles, DRB1*0107, *0425 and *13012 and confirmation of DRB4*01033. Tissue Antigens, 61: 398–402. doi: 10.1034/j.1399-0039.2003.00034.x
- Issue published online: 12 MAY 2003
- Article first published online: 12 MAY 2003
- Received 18 October 2002, revised 2 December 2002, accepted for publication 3 December 2002
- new allele;
- sequence-based typing
Abstract: The characterization of three novel DRB1 alleles is described, DRB1*0107, DRB1*0425 and DRB1*13012 as well as confirmation of DRB4*01033. Two alleles, DRB1*0107 and *0425, showed amino acid differences with previously identified HLA molecules. In DRB1*0107, the glutamine at position 10 was substituted by a glutamic acid. DRB1*0425 showed one amino acid difference with DRB1*0418 (I to F) at position 67, and five amino acid differences with DRB1*04011 at positions 67 (L to F), 70 (Q to D), 71 (K to R), 74 (A to L) and 86 (G to V). The alleles DRB1*13012 and DRB4*01033 had protein sequences identical to DRB1*13011 and DRB4*01031/01032, respectively. Nucleotide differences were present at position 306 for DRB1*13012 and at position 321 for DRB4*01033.