This review is based on the 3rd International HLA-G Conference held at the College de France, Paris, France, July 2003.
Biology and functions of human leukocyte antigen-G in health and sickness*
Article first published online: 16 SEP 2003
Volume 62, Issue 4, pages 273–284, October 2003
How to Cite
LeMaoult, J., Le Discorde, M., Rouas-Freiss, N., Moreau, P., Menier, C., McCluskey, J. and Carosella, E.D. (2003), Biology and functions of human leukocyte antigen-G in health and sickness. Tissue Antigens, 62: 273–284. doi: 10.1034/j.1399-0039.2003.00143.x
- Issue published online: 16 SEP 2003
- Article first published online: 16 SEP 2003
- Received and accepted for publication 31 July 2003
- expression regulation;
- immune inhibition;
Abstract: In 1998, the first International Conference on human leukocyte antigen-G (HLA-G) was held in Paris. At that time, HLA-G was still a new HLA class I molecule, few aspects of its immunological functions were known, and its expression by tumors was just being described. In 1998, tools to properly study HLA-G were lacking, especially monoclonal antibodies, and three conclusions were drawn after the congress: (i) animal models were needed, (ii) the biology of HLA-G isoforms had to be confirmed, and (iii) HLA-G expression by tumors required clarification. Five years later, these three issues have been addressed. HLA-G is now gaining pace and is investigated for its immuno-inhibitory functions in the context of multiple pathologies. Eighty five oral presentations were given this year for more than 200 investigators working on HLA-G by speakers from over 20 countries. The success of the 3rd International Conference on HLA-G reflects the interest and tremendous work of the many research teams which, over the years, contributed to the publication of more than 500 peer-review articles. We summarize the key points that were presented and discussed during this meeting.