Mutations in the gene for toll-like receptor 4 and multiple sclerosis

Authors


Markus Reindl, PhD
Department of Neurology
University of Innsbruck
Anichstrasse 35
A-6020 Innsbruck
Austria
Tel: +43 512504 4365
Fax: +43 512504 4266
e-mail: markus.reindl@uibk.ac.at

Abstract

Abstract: Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system with heterogeneous pathological features, disease courses and genetical backgrounds. In this study we determined whether genetic variants of toll-like receptor (TLR) 4, which confer substantial differences in the inflammation elicited by bacterial lipopolysaccharide, are related to the development of MS. We found no differences in the frequencies of the cosegregating TLR4 Asp299Gly and Thr399Ile polymorphisms between Austrian MS patients (11.6%) and age-matched controls (13.7%). Furthermore, we could not detect any influence of these mutations on clinical parameters and serum levels of soluble adhesion molecules of MS patients. Our data indicate that these TLR4 polymorphisms have no influence on the incidence, progression and inflammatory parameters of MS.

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