This study was supported in a part by a Grant-in-aid from the Ministry of Education, Science and Culture (04807055) of the Japanese Government.
Increased airway responsiveness to acetaldehyde in asthmatic subjects with alcohol-induced bronchoconstriction
Article first published online: 25 DEC 2001
European Respiratory Journal
Volume 14, Issue 1, pages 19–22, July 1999
How to Cite
Fujimura, M., Myou, S., Kamio, Y., Ishiura, Y., Iwasa, K., Hashimoto, T. and Matsuda, T. (1999), Increased airway responsiveness to acetaldehyde in asthmatic subjects with alcohol-induced bronchoconstriction. European Respiratory Journal, 14: 19–22. doi: 10.1034/j.1399-3003.1999.14a05.x
- Issue published online: 25 DEC 2001
- Article first published online: 25 DEC 2001
- alcohol-induced bronchoconstriction;
- bronchial responsiveness;
Bronchial responsiveness to acetaldehyde, a main factor in alcohol-induced bronchoconstriction, and methacholine were compared between 10 subjects with alcohol-induced bronchoconstriction and 16 asthmatic subjects without alcohol sensitivity.
In the alcohol-sensitive group, the geometric mean (geometric sem ( gsem)) of the provocative concentration of methacholine (PC20,meth) and acetaldehyde (PC20,acet) causing a 20% fall in forced expiratory volume in one second were 0.947 mg·mL-1 ( gsem 0.139) and 21.0 mg·mL-1 ( gsem 0.112), respectively, which were not significantly different from those in the nonalcohol-sensitive group, which were 0.634 mg·mL-1 ( gsem 0.115) and 31.7 mg·mL-1 ( gsem 0.077), respectively. The ratio of airway responsiveness to acetaldehyde relative to methacholine (log PC20,acet/PC20,meth) was 1.345±0.093 (mean±sem) in the alcohol-sensitive group, which was significantly different from the value of 1.699±0.059 in the nonalcohol-sensitive group (p=0.0025). A significant correlation was observed between PC20,meth and PC20,acet in both the alcohol-sensitive group (r=0.742, p=0.0115) and nonsensitive group (r=0.882, p<0.0001).
In conclusion, the airways of asthmatic subjects with alcohol-induced bronchoconstriction have a selective hyperresponsiveness to acetaldehyde.