This study was supported by a grant from Pharmacia & Upjohn, Helsingborg, Sweden and the Danish Lung Foundation.
Smoking cessation with four nicotine replacement regimes in a lung clinic
Article first published online: 25 DEC 2001
European Respiratory Journal
Volume 16, Issue 4, pages 717–722, October 2000
How to Cite
Tønnesen, P. and Mikkelsen, K.L. (2000), Smoking cessation with four nicotine replacement regimes in a lung clinic. European Respiratory Journal, 16: 717–722. doi: 10.1034/j.1399-3003.2000.16d25.x
- Issue published online: 25 DEC 2001
- Article first published online: 25 DEC 2001
- Cited By
- Lung clinic;
- nicotine inhaler;
- nicotine patch;
- smoking cessation
Smoking cessation is a key intervention for prevention of several lung diseases. The aim of the present study was to compare the effect of smoking cessation with nicotine replacement in a lung clinic in a low resource set-up suitable for implementation in other lung clinics.
This was an open, randomized trial with 4 different nicotine replacement regimes combined with minimal behavioural support in daily routine. A total of 446 smokers (>9 cigarettes·day-1) were allocated to a nurse-conducted smoking cessation programme with 4 treatment arms: a 5-mg nicotine patch (“placebo”), a 15-mg nicotine patch, nicotine inhaler, and a 15-mg nicotine patch plus nicotine inhaler. Recommended use of the nicotine products were 3 months with the possibility of continuing use up to 9 months on an individual basis. Individual follow-up studies were scheduled after 2 and 6 weeks, 3, 6, 9 and 12 months.
The 12-month point prevalence was 6% (5-mg patch (placebo)), 16% (15-mg patch) (p<0.05), 9% (inhaler) and 11% (15-mg patch plus inhaler), respectively.
To conclude, the set-up investigated in this study which included minimal beha-vioural support with nicotine patches should be evaluated in other lung clinics, as it doubled success rate when compared to a placebo with a 1-yr point prevalence of 16% and also the resources used are limited.