SEARCH

SEARCH BY CITATION

Keywords:

  • Boc;
  • dioxane;
  • hydrogen chloride;
  • selective deprotection;
  • tert-butyl ester

Abstract: Fast, efficient and selective deprotection of the tert-butoxycarbonyl (Boc) group of various amino acids and peptides was achieved by using hydrogen chloride (4 m) in anhydrous dioxane solution for 30 min at room temperature. In the cases studied in our laboratory, this protocol provided superior selectivity to deprotect Nα-Boc groups in the presence of tert-butyl esters and tert-butyl ethers, including thio-tert-butyl ethers, but not phenolic tert-butyl ethers.