Helicobacter pylori seropositivity in children with atopic dermatitis as sole manifestation of food allergy

Authors

  • Giovanni Corrado,

    1. Servizio Speciale di Gastroenterologia Pediatrica, Istituto di Clinica Pediatrica, Università degli Studi di Roma ‘La Sapienza’, Rome, Italy,
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  • Ida Luzzi,

    1. Laboratorio di Batteriologia e Micologia Medica, Istituto Superiore di Sanità, Rome, Italy
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  • Claudia Pacchiarotti,

    1. Servizio Speciale di Gastroenterologia Pediatrica, Istituto di Clinica Pediatrica, Università degli Studi di Roma ‘La Sapienza’, Rome, Italy,
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  • Sandra Lucarelli,

    1. Servizio Speciale di Gastroenterologia Pediatrica, Istituto di Clinica Pediatrica, Università degli Studi di Roma ‘La Sapienza’, Rome, Italy,
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  • Tullio Frediani,

    1. Servizio Speciale di Gastroenterologia Pediatrica, Istituto di Clinica Pediatrica, Università degli Studi di Roma ‘La Sapienza’, Rome, Italy,
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  • Marisa Cavaliere,

    1. Servizio Speciale di Gastroenterologia Pediatrica, Istituto di Clinica Pediatrica, Università degli Studi di Roma ‘La Sapienza’, Rome, Italy,
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  • Patrizia Rea,

    1. Servizio Speciale di Gastroenterologia Pediatrica, Istituto di Clinica Pediatrica, Università degli Studi di Roma ‘La Sapienza’, Rome, Italy,
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  • Ettore Cardi

    1. Servizio Speciale di Gastroenterologia Pediatrica, Istituto di Clinica Pediatrica, Università degli Studi di Roma ‘La Sapienza’, Rome, Italy,
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Dr Giovanni Corrado, Via di Vigna Stelluti 40, 00191 Rome, Italy
Tel.:./Fax: + 39 06 49218512
E-mail: gi.corrado@tiscalinet.it

Abstract

A positive association between Helicobacter pylori antibodies and food allergy presenting with gastrointestinal symptoms has recently been reported. A subset of a H. pylori strain possesses an antigen, CagA, as a virulence factor. Anti-H. pylori and anti-CagA IgG titre have been determined in children with atopic dermatitis (AD) as the sole clinical manifestation of food allergy. In this study, thirty patients with AD as the sole clinical manifestation of food allergy were examined (group A). For comparative purposes, 30 patients affected by food allergy with gastrointestinal symptoms (group B) and 30 affected by atopic asthma (group C) were studied. Anti-H. pylori and anti-CagA immunoglobulin G (IgG) were determined in all individuals by means of the enzyme-linked immunosorbent assay. The anti-H. pylori IgG titre was significantly higher in group A and group B vs. group C (p < 0.05); no significant difference was detected between group A and group B (p > 0.05). No significant difference in anti-CagA titre was found between the groups. These data demonstrate a positive association between H. pylori antibodies and AD as the sole manifestation of food allergy. Further investigations are needed to evaluate the cause–effect relationship between H. pylori seropositivity and AD.

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