Transplantation tolerance: The concept and its applicability

Authors

  • Victor M. Dong,

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    • * Co-first authors. This material was presented at the 3rd International Congress on Pediatric Transplantation, Boston, MA, USA, July 1998.

  • Karl L. Womer,

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    • * Co-first authors. This material was presented at the 3rd International Congress on Pediatric Transplantation, Boston, MA, USA, July 1998.

  • Mohamed H. Sayegh

    1. Laboratory of Immunogenetics and Transplantation, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
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Mohamed H. Sayegh, Laboratory of Immunogenetics and Transplantation, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis Street, Boston, Massachusetts, 02115, USA
Tel: (617) 732 5259
Fax: (617) 732–5254
E-mail: msayegh@rics.bwh.harvard.edu

Abstract

Abstract: Recent advances have enabled researchers to induce tolerance in animal transplant models. Although it has been relatively easy to do so in rodents, it has been much more difficult to translate such strategies into primates. Understanding the cellular and molecular mechanisms of the alloimmune response has prompted the development of novel strategies that may obviate the need for immunosuppression in humans. Mechanisms of tolerance and promising new therapies, as well as the inherent difficulties in bringing them into clinical practice, are reviewed.

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