Effects of immunosuppression and organ transplantation on the natural history and immunopathogenesis of hepatitis C virus infection
Article first published online: 25 DEC 2001
Transplant Infectious Disease
Volume 2, Issue 4, pages 166–185, December 2000
How to Cite
McCaughan, G.W. and Zekry, A. (2000), Effects of immunosuppression and organ transplantation on the natural history and immunopathogenesis of hepatitis C virus infection. Transplant Infectious Disease, 2: 166–185. doi: 10.1034/j.1399-3062.2000.020403.x
The role of the immune response in the pathogenesis of liver injury during hepatitis C viral infection remains to be clarified. In the immunologically normal host, liver injury is largely mediated by the host’s immune response. By contrast, McCaughan and Zekry review the available data, which suggest that, in the immunocompromised host, viral cytopathogenicity dominates the progression of liver disease. This observation demonstrates the acute need for improved antiviral therapies. The balance between immune suppression and the management of HCV infection in transplantation is precarious. Given the impact of acute rejection on disease progression and the possible links between HCV, stimulation of B-cell proliferation and PTLD, new strategies for the management of this infection remain critical.
Jay A. Fishman, MD
Editor, Basic Science
- Issue published online: 25 DEC 2001
- Article first published online: 25 DEC 2001
- Received 28 February, revised 4 May, accepted for publication 4 May 2000
Options for accessing this content:
- If you have access to this content through a society membership, please first log in to your society website.
- If you would like institutional access to this content, please recommend the title to your librarian.
- Login via other institutional login options http://onlinelibrary.wiley.com/login-options.
- You can purchase online access to this Article for a 24-hour period (price varies by title)
- New Users: Please register, then proceed to purchase the article.
Login via OpenAthens
Search for your institution's name below to login via Shibboleth.
Registered Users please login:
- Access your saved publications, articles and searches
- Manage your email alerts, orders and subscriptions
- Change your contact information, including your password
Please register to:
- Save publications, articles and searches
- Get email alerts
- Get all the benefits mentioned below!
Patients and/or caregivers may access this content for use in relation to their own personal healthcare or that of a family member only. Terms and conditions will apply.