Effects of immunosuppression and organ transplantation on the natural history and immunopathogenesis of hepatitis C virus infection
Article first published online: 25 DEC 2001
Transplant Infectious Disease
Volume 2, Issue 4, pages 166–185, December 2000
How to Cite
McCaughan, G.W. and Zekry, A. (2000), Effects of immunosuppression and organ transplantation on the natural history and immunopathogenesis of hepatitis C virus infection. Transplant Infectious Disease, 2: 166–185. doi: 10.1034/j.1399-3062.2000.020403.x
The role of the immune response in the pathogenesis of liver injury during hepatitis C viral infection remains to be clarified. In the immunologically normal host, liver injury is largely mediated by the host’s immune response. By contrast, McCaughan and Zekry review the available data, which suggest that, in the immunocompromised host, viral cytopathogenicity dominates the progression of liver disease. This observation demonstrates the acute need for improved antiviral therapies. The balance between immune suppression and the management of HCV infection in transplantation is precarious. Given the impact of acute rejection on disease progression and the possible links between HCV, stimulation of B-cell proliferation and PTLD, new strategies for the management of this infection remain critical.
Jay A. Fishman, MD
Editor, Basic Science
- Issue published online: 25 DEC 2001
- Article first published online: 25 DEC 2001
- Received 28 February, revised 4 May, accepted for publication 4 May 2000
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