Burkholderia cepacia complex: a contraindication to lung transplantation in cystic fibrosis?
Article first published online: 23 DEC 2001
Transplant Infectious Disease
Volume 3, Issue 3, pages 149–160, September 2001
How to Cite
LiPuma, J.J. (2001), Burkholderia cepacia complex: a contraindication to lung transplantation in cystic fibrosis?. Transplant Infectious Disease, 3: 149–160. doi: 10.1034/j.1399-3062.2001.003003149.x
- Issue published online: 23 DEC 2001
- Article first published online: 23 DEC 2001
- Received 16 November 2000, revised, accepted for publication 23 April 2001
- Burkholderia cepacia complex;
- cystic fibrosis
Abstract: Previous studies have indicated that pulmonary infection with Burkholderia cepacia is associated with poor clinical outcome after lung transplantation in cystic fibrosis (CF). Many treatment centers consider B. cepacia infection an absolute contraindication to lung transplantation. However, the B. cepacia complex actually consists of several closely related bacterial species. Although each of these has been isolated from CF sputum culture, certain species are much more frequently recovered than others, and it is not yet clear whether all species have the same potential for virulence in CF. Additional study is needed to better define the relative risks associated with each species of the B. cepacia complex.