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Burkholderia cepacia complex: a contraindication to lung transplantation in cystic fibrosis?


Dr John J. LiPuma
Department of Pediatrics and Communicable Diseases
University of Michigan Medical School
1150 W Medical Center Drive
8323 MSRB III, Box 0646
Ann Arbor, MI 48109-0646
Tel: +734 936 9767
Fax: +734 764 4279


Abstract: Previous studies have indicated that pulmonary infection with Burkholderia cepacia is associated with poor clinical outcome after lung transplantation in cystic fibrosis (CF). Many treatment centers consider B. cepacia infection an absolute contraindication to lung transplantation. However, the B. cepacia complex actually consists of several closely related bacterial species. Although each of these has been isolated from CF sputum culture, certain species are much more frequently recovered than others, and it is not yet clear whether all species have the same potential for virulence in CF. Additional study is needed to better define the relative risks associated with each species of the B. cepacia complex.