*All authors were invited members of the Novartis, Xenotransplantation Safety Advisory Board. BWJM's contributions were made in a private capacity; no official support or endorsement by the Centers for Disease, Control and Prevention is intended or should be inferred. ‡PDM had observer status on the Novartis Xenotransplantation, Safety Advisory Board.
An approach to the control of disease transmission in pig-to-human xenotransplantation
Article first published online: 25 DEC 2001
Volume 7, Issue 2, pages 143–155, May 2000
How to Cite
Onions, D., Cooper, D. K. C., Alexander, T. J. L., Brown, C., Claassen, E., Foweraker, J. E., Harris, D. L., Mahy, B. W. J., Minor, P. D., Osterhaus, A. D. M. E., Pastoret, P.-P. and Yamanouchi, K. (2000), An approach to the control of disease transmission in pig-to-human xenotransplantation. Xenotransplantation, 7: 143–155. doi: 10.1034/j.1399-3089.2000.00047.x
- Issue published online: 25 DEC 2001
- Article first published online: 25 DEC 2001
- Received 30 November 1999;Accepted 29 February 2000
- Cited By
- endogenous retroviruses;
Abstract: Although several major immunologic hurdles need to be overcome, the pig is currently considered the most likely source animal of cells, tissues and organs for transplantation into humans. Concerns have been raised with regard to the potential for the transfer of infectious agents with the transplanted organ to the human recipient. This risk is perceived to be increased as it is likely that the patient will be iatrogenically immunocompromised and the organ-source pig may be genetically engineered in such a way to render its organs particularly susceptible to infection with human viruses. Furthermore, the risk may not be restricted to the recipient, but may have consequences for the health of others in the community. The identification of porcine endogenous retroviruses and of hitherto unknown viruses have given rise to the most concern. We document here the agents we believe should be excluded from the organ-source pigs. We discuss the likelihood of achieving this aim and outline the potential means by which it may best be achieved.