Phenotypic spectra of bipolar disorder in responders to lithium versus lamotrigine
Article first published online: 7 APR 2003
Volume 5, Issue 2, pages 110–114, April 2003
How to Cite
Passmore, M. J., Garnham, J., Duffy, A., MacDougall, M., Munro, A., Slaney, C., Teehan, A. and Alda, M. (2003), Phenotypic spectra of bipolar disorder in responders to lithium versus lamotrigine. Bipolar Disorders, 5: 110–114. doi: 10.1034/j.1399-5618.2003.00026.x
- Issue published online: 7 APR 2003
- Article first published online: 7 APR 2003
- Received 6 August 2002, revised and accepted for publication 29 November 2002
- bipolar disorder;
Objective: We conducted a study of clinical presentation and family history in patients responsive to either of two commonly used mood stabilizers, lithium and lamotrigine.
Methods: The sample included 164 subjects from 21 families of bipolar probands, 14 responders to lithium and seven to lamotrigine. Diagnostic information on first-degree relatives was obtained in a blind fashion through a combination of direct interviews (SADS-L) and family history assessments (FH-RDC).
Results: The probands differed with respect to clinical course (episodic in the lithium group, rapid cycling in the lamotrigine group), and comorbidity (panic attacks and substance abuse in the lamotrigine group). The relatives of lithium responders had significantly higher risk of bipolar disorder while relatives of lamotrigine responders had higher prevalence of schizoaffective disorder, major depression and panic attacks.
Conclusions: These findings suggest that lithium- and lamotrigine-responsive patients differ with respect to course of illness, comorbidity and family history and may represent distinct subtypes of bipolar disorder.