Subsyndromal symptoms assessed in longitudinal, prospective follow-up of a cohort of patients with bipolar disorder
Version of Record online: 3 OCT 2003
Volume 5, Issue 5, pages 349–355, October 2003
How to Cite
MacQueen, G. M., Marriott, M., Begin, H., Robb, J., Joffe, R. T. and Young, L. T. (2003), Subsyndromal symptoms assessed in longitudinal, prospective follow-up of a cohort of patients with bipolar disorder. Bipolar Disorders, 5: 349–355. doi: 10.1034/j.1399-5618.2003.00048.x
- Issue online: 3 OCT 2003
- Version of Record online: 3 OCT 2003
- Received 8 November 2002, revised and accepted for publication 17 February 2003
- course of illness;
- subsyndromal symptoms
Background: Many patients with bipolar disorder (BD) do not regain full function following an acute illness episode, but the extent to which this impairment is the result of persistent symptoms has not been well established. This study examined factors associated with persistent subsyndromal symptoms in a well characterized group of BD patients who were prospectively followed for an average of 3 years.
Methods: Detailed life charting data from 138 patients with BD were reviewed. Patients were categorized into euthymic, subsyndromal or syndromal groups according to the clinical state during their most recent year of follow-up. The three groups were then examined with respect to comorbidity, function and treatment received.
Results: Patients with subsyndromal symptoms had high rates of comorbid anxiety disorders, and were more likely to have increased rates of eating disorders as well. Patients with subsyndromal symptoms had lower global assessment of function (GAF) scores than euthymic patients, and had as many clinic contacts and medication trials as patients with full episodes of illness.
Conclusions: Persistent subsyndromal symptoms in BD patients are associated with high rates of comorbidity that is important to recognize and treat in order to optimize mood and functioning.