Ictal onset localization of epileptic seizures by magnetoencephalography


Dr med. univ. Christian Tilz, Department of Neurology, University of Erlangen-Nuernberg, Schwabachanlage 6, Erlangen, 91054, Germany
Tel.: +49 9131 8536921
Fax: +49 9131 85 36 469
e-mail: christian.tilz@neuro.med.uni-erlangen.de


Objective– The aim of this study was to localize the ictal onset zone of focal epileptic seizures by magnetoencephalography (MEG) and to compare the results with interictal MEG localizations, ictal and interictal electroencephalography (EEG) results and magnetic resonance imaging (MRI) in epilepsy surgery candidates. Material and methods – Data of 13 patients with partial seizures during MEG recording were analysed. Measurements were performed with a Magnes II dual unit system. Results– In six of 13 cases, the ictal onset zone could be localized by MEG, with all interictal MEG findings being confirmed by ictal MEG results. In four cases, the ictal MEG localization results were corresponding to the ictal EEG localization results. In two cases, EEG yielded no comparable information. Conclusion – Ictal onset localization is feasible with MEG. Both interical and ictal MEG contribute valuable information to the presurgical assessment of epilepsy patients.