Gender differences in disability and health-related quality of life in patients with Parkinson's disease treated with stereotactic surgery
Article first published online: 16 JUN 2003
Acta Neurologica Scandinavica
Volume 108, Issue 1, pages 28–37, July 2003
How to Cite
Hariz, G.-M., Lindberg, M., Hariz, M. I. and Tommy Bergenheim, A. (2003), Gender differences in disability and health-related quality of life in patients with Parkinson's disease treated with stereotactic surgery. Acta Neurologica Scandinavica, 108: 28–37. doi: 10.1034/j.1600-0404.2003.00092.x
- Issue published online: 16 JUN 2003
- Article first published online: 16 JUN 2003
- Accepted for publication October 29, 2002
- activities of daily living;
- deep brain stimulation;
- health-related quality of life;
- Parkinson's disease
Objectives – To investigate eventual differences between women and men with Parkinson's disease (PD) before and after surgery, with respect to clinical status, disability and health-related quality of life (HRQoL).
Material and methods – Twenty-four men and 14 women with PD received a total of 46 surgical procedures (pallidotomy, thalamotomy and deep brain stimulation of the thalamus, pallidum or subthalamic nucleus). The impact of PD on disability and other aspects of HRQoL was analysed separately in men and women before and at a mean of 11 months after surgery, using the following assessment tools: The Unified Parkinson's Disease Rating Scale (UPDRS), the ADL Taxonomy, the Nottingham Health Profile, the Life Satisfaction Questionnaire and a Visual Analogue Scale.
Results – At surgery, women had a significantly longer duration of disease than men (mean: 15 vs. 10 years, P < 0.01). They had a higher stage on the Hoehn and Yahr scale and worse scores on UPDRS parts II (ADL) and IV (complications), as well as on the Schwab and England scale and on the ADL Taxonomy. Following surgery, both men and women showed improvement, but women experienced greater benefit than men in ADL, in emotions, and in social life.
Conclusions – Perhaps women with PD should be offered surgery more often and earlier in the course of their disease.