Risk for anogenital cancer and other cancer among women hospitalized with gonorrhea
Article first published online: 20 DEC 2001
Acta Obstetricia et Gynecologica Scandinavica
Volume 80, Issue 8, pages 757–761, August 2001
How to Cite
Johansen, C., Mellemkjær, L., Frisch, M., Kjær, S. K., Gridley, G. and Olsen, J. H. (2001), Risk for anogenital cancer and other cancer among women hospitalized with gonorrhea. Acta Obstetricia et Gynecologica Scandinavica, 80: 757–761. doi: 10.1034/j.1600-0412.2001.080008757.x
- Issue published online: 20 DEC 2001
- Article first published online: 20 DEC 2001
- Submitted 12 January, 2001Accepted 27 March, 2001
Background. We investigated the relationship between infections with Neisseria gonorrhoeae and anogenital and other cancers.
Methods. Nationwide and population based register linkage study utilizing prospectively notified information. The observed numbers of cancers among the women were compared with those expected on the basis of national incidence rates.
Results. In a cohort of 4440 women hospitalized for gonorrhea we observed a total of 227 cases of cervical intraepithelial neoplasia grade III (CIN III), with 103 expected (standardized incidence ratio (SIR), 2.2; 95% confidence interval (CI), 1.9–2.5). No significantly increased risk for other anogenital cancers or cancer at other sites was seen.
Conclusions. These results support the view that the observed association between gonorrheal infection and subsequent cervical preneoplasia is due mainly to surveillance bias. However, our results also indicate that women hospitalized with a N. gonorrhoeae infection will benefit from the compliance with the regular Pap smear screening programs.