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Keywords:

  • transforming growth factor-beta 1;
  • pregnancy;
  • pre-eclampsia;
  • serum

Background.  Isoforms of transforming growth factor-beta (TGF-β1) are thought to be involved in the pathogenesis of pre-eclampsia. Data with respect to TGF-β1 are controversial. We examined the correlation between TGF-β1 serum levels and the occurrence and severity of pre-eclampsia.

Methods.  Transforming growth factor-beta 1 serum levels were measured using a commercially available enzyme-linked immunosorbent assay in 44 women with pre-eclampsia and 44 healthy pregnant women. Results were correlated with clinical data.

Results.  No difference in TGF-β1 serum levels was assessed between women with pre-eclampsia and healthy pregnant women. Transforming growth factor-beta 1 serum levels were not associated with the severity of the disease and were not correlated with clinical maternal (blood pressure, proteinuria) and fetal (5-min APGAR score, umbilical cord pH values, birth weight) parameters.

Conclusions.  Our data support the assumption that in contrast to other isoforms, TGF-β1, as evidenced by serum TGF-β1 levels, does not seem to be involved in the pathogenesis of pre-eclampsia.