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Keywords:

  • Hormone replacement therapy;
  • randomised clinical trial;
  • HERS II;
  • WHI study;
  • primary prevention;
  • coronary heart disease;
  • stroke;
  • venous thrombosis;
  • pulmonary embolism;
  • conjugated estrogens;
  • progestins;
  • medroxyprogesterone acetate

In the Nordic countries the prevalence of hormonal replacement therapy (HRT) use in women from 50 to 70 years of age is slightly above 30% evaluated by sales figures and with some variation between the five countries.

The premise for this commentary is to discuss the best clinical practice when prescribing HRT to post menopausal women following the publication of the most recent evidence from two well conducted randomized placebo controlled trials, namely the Heart and Estrogen/Progestin Replacement Study II (HERS II) and the Women's Health Initiative study (WHI ).