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Keywords:

  • 5-fluorouracil (5-FU);
  • drug side effects;
  • ocular toxicity;
  • epiphora;
  • canalicular stenosis;
  • cancer chemotherapy

ABSTRACT.

Purpose: Ocular side effects of systemic 5-fluorouracil therapy include excessive lacrimation which often resolves on cessation of therapy. Permanent stenosis of lacrimal puncta and canaliculi is rare. This report highlights this uncommon complication of 5-fluorouracil therapy.

Methods: Report of two cases and review of literature.

Results: Severe stenosis of puncta and canaliculi may be associated with prolonged systemic 5-fluorouracil therapy.

Conclusion: It is important for both the oncologist and ophthalmologist to be aware of the potential ocular toxicity of 5-fluorouracil. Surgical management to relieve the epiphora is often challenging, and early intervention may be beneficial.