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Factor V Leiden and prothrombin gene G20210A mutations in ocular Behçet disease

  1. Figen Batioğlu1,*,
  2. Leyla S. Atmaca1,
  3. Halil Gürhan Karabulut2,
  4. Derya Beyza Sayin2

Article first published online: 29 MAY 2003

DOI: 10.1034/j.1600-0420.2003.00068.x

Issue

Acta Ophthalmologica Scandinavica

Acta Ophthalmologica Scandinavica

Volume 81, Issue 3, pages 283–285, June 2003

Additional Information

How to Cite

Batioğlu, F., Atmaca, L. S., Karabulut, H. G. and Beyza Sayin, D. (2003), Factor V Leiden and prothrombin gene G20210A mutations in ocular Behçet disease. Acta Ophthalmologica Scandinavica, 81: 283–285. doi: 10.1034/j.1600-0420.2003.00068.x

Author Information

  1. 1

    Eye Clinic, Medical School, Ankara University, Turkey

  2. 2

    Medical Genetics, Medical School, Ankara University, Turkey

*Figen Batioğlu MD Güzaltan sokak 22/6 06570 Ankara Turkey Tel: + 90 312 23 04 064 Email: fbatioglu@hotmail.com

Publication History

  1. Issue published online: 29 MAY 2003
  2. Article first published online: 29 MAY 2003
  3. Received on July 30th, 2002. Accepted on January 20th, 2003.

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Keywords:

  • Behçet's disease;
  • procoagulant factors;
  • factor V Leiden mutation;
  • prothrombin G20210A-mutation;
  • vascular occlusion

Abstract.

Purpose:  To investigate genetic prothrombotic factors (factor V Leiden and prothrombin gene G20210A mutations) and their relation with retinal vascular occlusions in ocular Behçet disease.

Methods:  Thirty Behçet patients were prospectively recruited into the study. Their mean age was 34.2 ± 8.3 years. All patients underwent complete ophthalmic examination and fluorescein angiography. Of the 30 patients, 15 (16 eyes) had retinal vascular occlusion. Patients were tested for the presence of factor V Leiden and prothrombin gene G20210A mutations by polymerase chain reaction. The results were compared with the frequencies of factor V Leiden in 285 and prothrombin gene G20210A mutation in 182 healthy members of the Turkish population.

Results:  The prevalence of factor V Leiden mutation was significantly higher in ocular Behçet patients (12/30, 40%), compared with healthy control subjects (28/285, 9.8%) (p < 0.001). Of the 12 Behçet patients with factor V Leiden mutation, eight had retinal vascular occlusion. The prevalence of factor V Leiden was 53.3% (8/15) of the 15 patients with retinal vascular occlusion and 26.7% (4/15) of the remaining 15 patients without vascular occlusion. Prothrombin gene mutation was detected in none of Behçet patients compared with 2.7% (5/182) of the control group.

Conclusion:  These data suggest that factor V Leiden may be an additional risk factor in ocular Behçet disease, whereas factor II mutations do not seem to be relevant.

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