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Frequency of HLA class 1 and 2 alleles in Brazilian patients with AIDS and cytomegalovirus retinitis

  1. Maria De Lourdes Veronese Rodrigues*,
  2. José Fernando De Castro Figueiredo,
  3. Neifi Hassan Saloum Deghaide,
  4. Erasmo Romão,
  5. Nivaldo Vieira De Souza,
  6. Eduardo Antonio Donadi

Article first published online: 26 SEP 2003

DOI: 10.1034/j.1600-0420.2003.00098.x

Issue

Acta Ophthalmologica Scandinavica

Acta Ophthalmologica Scandinavica

Volume 81, Issue 5, pages 514–516, October 2003

Additional Information

How to Cite

De Lourdes Veronese Rodrigues, M., De Castro Figueiredo, J. F., Deghaide, N. H. S., Romão, E., De Souza, N. V. and Donadi, E. A. (2003), Frequency of HLA class 1 and 2 alleles in Brazilian patients with AIDS and cytomegalovirus retinitis. Acta Ophthalmologica Scandinavica, 81: 514–516. doi: 10.1034/j.1600-0420.2003.00098.x

Author Information

  1. Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil

* Professor Dr Maria de Lourdes Veronese Rodrigues Hospital das Clínicas Oftalmologia 12 andar Campus USP 14048-900 Ribeirão Preto São Paolo Brazil Tel: + 55 16 602 2523 Fax: + 55 16 602 2860 Email: mdlvrodr@fmrp.usp.br

Publication History

  1. Issue published online: 26 SEP 2003
  2. Article first published online: 26 SEP 2003
  3. Received on October 29th, 2002. Accepted on April 1st, 2003.

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Keywords:

  • cytomegalovirus retinitis;
  • histocompatibility leucocyte antigens;
  • acquired immunodeficiency syndrome;
  • risk factor

Abstract.

Purpose: To evaluate the human leucocyte antigen (HLA) class 1 (HLA-A and HLA-B) and HLA class 2 (HLA-DRB1 and HLA-DQB1) allele profiles in the susceptibility to cytomegalovirus retinitis (CMV-R) in patients with AIDS.

Methods: Cytomegalovirus retinitis was clinically diagnosed by indirect binocular ophthalmoscopy. Human leucocyte antigens class 1 were typed using a complement-dependent microlymphocytotoxicity assay, and HLA class 2 alleles were identified using amplified DNA hybridized to sequence-specific oligonucleotide primers.

Results: The frequencies of HLA class 1 antigens and HLA class 2 alleles observed in patients and controls were similar; however, HLA-A31 antigen was over-represented in patients with AIDS, independent of the presence of CMV-R.

Conclusion: There was no association between HLA molecules/alleles and CMV-R in Brazilian patients with AIDS. However, the results support the role of the HLA system in the susceptibility to developing AIDS.

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