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Detection of oncogenic human papillomavirus in sporadic retinoblastoma

  1. M. A. Palazzi1,*,
  2. J. A. Yunes1,
  3. I. A. Cardinalli1,
  4. G. P. Stangenhaus1,
  5. S. R. Brandalise1,
  6. S. A. Ferreira2,
  7. J. S. P. Sobrinho2,
  8. L. L. Villa2

Article first published online: 11 JUL 2003

DOI: 10.1034/j.1600-0420.2003.00112.x

Issue

Acta Ophthalmologica Scandinavica

Acta Ophthalmologica Scandinavica

Volume 81, Issue 4, pages 396–398, August 2003

Additional Information

How to Cite

Palazzi, M. A., Yunes, J. A., Cardinalli, I. A., Stangenhaus, G. P., Brandalise, S. R., Ferreira, S. A., Sobrinho, J. S. P. and Villa, L. L. (2003), Detection of oncogenic human papillomavirus in sporadic retinoblastoma. Acta Ophthalmologica Scandinavica, 81: 396–398. doi: 10.1034/j.1600-0420.2003.00112.x

Author Information

  1. 1

    Boldrini Children's Centre, Campinas, São Paulo, Brazil

  2. 2

    Ludwig Institute for Cancer Research, São Paulo, Brazil

*Maristela A. Palazzi MD Rua Décio de Almeida Filho 421 Campinas 13084-710 São Paulo Brazil Tel: + 55 21 3289 5502 Fax: + 55 21 3289 5502 Email: palazzi@lexxa.com.br

Publication History

  1. Issue published online: 11 JUL 2003
  2. Article first published online: 11 JUL 2003
  3. Received on December 4th, 2002. Accepted on April 26th, 2003.

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Keywords:

  • retinoblastoma;
  • human papillomavirus;
  • HPV detection;
  • eye;
  • polymerase chain reaction

Abstract.

Purpose:  To investigate the presence of human papillomavirus (HPV) DNA in tumour tissue from patients with unilateral retinoblastoma.

Methods:  Samples of paraffin-embedded tumour tissue from 43 children with unilateral retinoblastoma were collected to investigate the presence of HPV DNA using polymerase chain reaction (PCR) and dot blot hybridization.

Results:  Oncogenic HPV DNA types 16 and 35 were detected in 12 (27.9%) of 43 tumour specimens. A higher frequency of differentiated tumours (63.3%) was observed among the HPV-positive tumours.

Conclusions:  Future studies are necessary to demonstrate an association between HPV and sporadic retinoblastoma.

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