A preliminary version of this paper was read at the 2nd International Zurich Conference on Clinical and Social Psychiatry, Zurich, 6–8 September 2001. The symposium and this publication were sponsored by Eli Lilly Suisse.
Life events and affective disorders
Article first published online: 4 SEP 2003
Acta Psychiatrica Scandinavica
Volume 108, Issue Supplement s418, pages 61–66, October 2003
How to Cite
Paykel, E. S. (2003), Life events and affective disorders. Acta Psychiatrica Scandinavica, 108: 61–66. doi: 10.1034/j.1600-0447.108.s418.13.x
- Issue published online: 4 SEP 2003
- Article first published online: 4 SEP 2003
- life events;
Objective: To summarize research in life events and affective disorders
Method: Review of the literature.
Results and conclusion: Many studies have shown that episodes of unipolar depression are preceded by life events at higher rates than in control samples. A variety of stressful events are involved with only limited specificity but some relationship to social exit events. Life events also affect remission and relapse of depression. Effects of life events are less when the disorder has already been recurrent, particularly where illness is severe. Effects of life events are also weaker in bipolar disorder than unipolar, but major life events may be important in first onset. Recent evidence suggests a specific role of social rhythm disruption events in manic relapses. Causative chains are multifactorial and complex, and genetic factors can influence life event exposure.