Brain imaging in childhood- and adolescence-onset schizophrenia associated with obsessive-compulsive symptoms
Article first published online: 24 DEC 2001
Acta Psychiatrica Scandinavica
Volume 102, Issue 1, pages 32–37, July 2000
How to Cite
Aoyama, F., Iida, J., Inoue, M., Iwasaka, H., Sakiyama, S., Hata, K. and Kishimoto, T. (2000), Brain imaging in childhood- and adolescence-onset schizophrenia associated with obsessive-compulsive symptoms. Acta Psychiatrica Scandinavica, 102: 32–37. doi: 10.1034/j.1600-0447.2000.102001032.x
- Issue published online: 24 DEC 2001
- Article first published online: 24 DEC 2001
- Accepted for publication December 27, 1999
- Cited By
- magnetic resonance imaging;
- childhood and adolescence;
- obsessive-compulsive symptoms;
Objective: Childhood- and adolescence-onset schizophrenic patients with obsessive-compulsive symptoms (OCS) constitute a specific subgroup of schizophrenia. We performed magnetic resonance imaging in this group seeking evidence of neurodevelopmental insults.
Method: Thirty-two schizophrenic patients were compared with 19 controls. Schizophrenic subjects were divided into 15 patients with OCS (SOCS+ group; onset at 15.5±1.6 years) and 17 without OCS (SOCS− group; onset at 15.3±1.3 years). Areas of the hippocampus, frontal lobe, corpus callosum and putamen were analysed morphometrically.
Results: The left hippocampus was significantly smaller in the SOCS+ group than in the SOCS− and control groups.
Conclusion: Reduced size of the left hippocampus in the SOCS+ group supports a neurodevelopmental etiology in this subgroup.