Early detection and intervention in first-episode schizophrenia: a critical review
Article first published online: 20 DEC 2001
Acta Psychiatrica Scandinavica
Volume 103, Issue 5, pages 323–334, May 2001
How to Cite
Larsen, T. K., Friis, S., Haahr, U., Joa, I., Johannessen, J. O., Melle, I., Opjordsmoen, S., Simonsen, E. and Vaglum, P. (2001), Early detection and intervention in first-episode schizophrenia: a critical review. Acta Psychiatrica Scandinavica, 103: 323–334. doi: 10.1034/j.1600-0447.2001.00131.x
- Issue published online: 20 DEC 2001
- Article first published online: 20 DEC 2001
- Accepted for publication October 9, 2000
- first-episode psychosis;
- early intervention
Objective: To review the literature on early intervention in psychosis and to evaluate relevant studies.
Method: Early intervention was defined as intervention in the prodromal phase (primary prevention) and intervention after the onset of psychosis, i.e. shortening of duration of untreated psychosis (DUP) (secondary prevention).
Results: We found few studies aimed at early intervention, but many papers discussing the idea at a more general level. We identified no studies that prove that intervention in the prodromal phase is possible without a high risk for treating false positives. We identified some studies aimed at reducing DUP, but the results are ambiguous and, until now, no follow-up data showing a positive effect on prognosis have been presented.
Conclusion: Early intervention in psychosis is a difficult and important challenge for the psychiatric health services. At the time being reduction of DUP seems to be the most promising strategy. Intervention in the prodromal phase is more ethically and conceptually problematic.