Citalopram versus nortriptyline in late-life depression: a 12-week randomized single-blind study
Article first published online: 20 DEC 2001
Acta Psychiatrica Scandinavica
Volume 103, Issue 6, pages 435–440, June 2001
How to Cite
Navarro, V., Gastó, C., Torres, X., Marcos, T. and Pintor, L. (2001), Citalopram versus nortriptyline in late-life depression: a 12-week randomized single-blind study. Acta Psychiatrica Scandinavica, 103: 435–440. doi: 10.1034/j.1600-0447.2001.00228.x
- Issue published online: 20 DEC 2001
- Article first published online: 20 DEC 2001
- Accepted for publication February 6, 2001
- major depression
Objective: The aim of this single-blind study was to examine the efficacy and tolerability of citalopram compared to nortriptyline in moderate to severe major depressive patients aged 60 years or over.
Method: In- and out-patients (N=58) with unipolar major depression were randomized to 12-week flexible dose treatment with nortriptyline or citalopram.
Results: No significant differences between the number of drop-outs in either group were observed, but the autonomic side-effects were significantly higher for nortriptyline than for citalopram. A significantly higher remission rate to nortriptyline than to citalopram was demonstrated, particularly if severe patients (endogenous or psychotic patients) were assessed.
Conclusion: The remission rate to a therapeutic plasma level of nortriptyline appears to be higher than the remission rate to a standard dose of citalopram in a group of elderly major depressed patients, especially those with endogenous or psychotic features. On the other hand, citalopram appears to be better tolerated.